Phosphorus-nitrogen compounds: Part 46. The reactions of N3P3Cl6 with bidentate and monodentate ligands: The syntheses, structural characterizations, antimicrobial and cytotoxic activities, and DNA interactions of (N/N)spirocyclotriphosphazenes with 4-chlorobenzyl pendant arm

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dc.contributor.authorAsmafiliz, Nuran
dc.contributor.authorBerberoglu, Ipek
dc.contributor.authorOzgur, Mehtap
dc.contributor.authorKilic, Zeynel
dc.contributor.authorKayalak, Hande
dc.contributor.authorAcik, Leyla
dc.contributor.authorHokelek, Tuncer
dc.date.accessioned2020-06-25T18:30:42Z
dc.date.available2020-06-25T18:30:42Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionOzgur, mehtap/0000-0002-6237-8522; Asmafiliz, Nuran/0000-0002-9335-4101
dc.description.abstractIn the present study, the partly and fully-substituted monospiro (4-6, 4a-6d), cis-dispiro (7-9), trans-dispiro (10-15) cyclotriphosphazenes were synthesized for the investigations of their chemical, stereogenic and biological properties. The cis/trans phosphazenes (7-12) have two stereogenic P centers. They are expected to be in meso and racemic forms. In addition, the structures of four compounds were evaluated using X-ray crystal-lographic data. Compound 13 was found to be a single enantiomer (RR) in the solid state, as also proved with its CD spectrum. The antibacterial and antifungal activities of the phosphazenes were elucidated for against Gram-positive (G+) and Gram-negative (G-) bacteria, and yeast strains, respectively. Of the compounds, 14 exhibits strong antimicrobial activity against most of the tested organisms, especially B. cereus and E. hirae. MBC and MFC values of compounds on different bacterial and fungal species ranged from < 9.8 mu M to 2500 mu M. Furthermore, the cytotoxic activities of 6, 4c, 10 and 14 were investigated against L929 fibroblast and DLD-1 cells, and 14 was the most cytotoxic compound against DLD-1.en_US
dc.description.sponsorshipScientific and Technical Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [116Z400]; Turkish Academy of Sciences (TUBA)Turkish Academy of Sciences; Hacettepe University Scientific Research Project UnitHacettepe University [013 D04 602 004]en_US
dc.description.sponsorshipThe authors acknowledge the Scientific and Technical Research Council of Turkey Grant No. 116Z400. Z. K. thanks the Turkish Academy of Sciences (TUBA) for partial support of this work. T. H. is grateful to Hacettepe University Scientific Research Project Unit (Grant No. 013 D04 602 004).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ica.2019.05.048
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-85067225799
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.ica.2019.05.048
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7705
dc.identifier.volume495en_US
dc.identifier.wosWOS:000481728800018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMonospiro and dispiroferrocenylphosphazenesen_US
dc.subjectCrystal structureen_US
dc.subjectSpectroscopyen_US
dc.subjectCytotoxicityen_US
dc.subjectAntimicrobial activityen_US
dc.subjectDNA cleavageen_US
dc.titlePhosphorus-nitrogen compounds: Part 46. The reactions of N3P3Cl6 with bidentate and monodentate ligands: The syntheses, structural characterizations, antimicrobial and cytotoxic activities, and DNA interactions of (N/N)spirocyclotriphosphazenes with 4-chlorobenzyl pendant armen_US
dc.typeArticle

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