Novel fluorescent coumarin-thiophene-derived Schiff bases: Synthesis, effects of substituents, photophysical properties, DFT calculations, and biological activities

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dc.contributor.authorYahaya, Issah
dc.contributor.authorChemchem, Meryem
dc.contributor.authorAydiner, Burcu
dc.contributor.authorSeferoglu, Nurgul
dc.contributor.authorTepe, Fulya Erva
dc.contributor.authorAcik, Leyla
dc.contributor.authorSeferoglu, Zeynel
dc.date.accessioned2020-06-25T18:34:42Z
dc.date.available2020-06-25T18:34:42Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionAYDINER, BURCU/0000-0003-1823-6217
dc.description.abstractNovel fluorescent coumarin-thiophene appended Schiff bases have been synthesized in good yields (76-89%). The effects of substitution on the fluorescent intensity and solubility of the molecules were examined with experimental techniques. The deprotonation properties of the prepared Schiff bases were examined, in DMSO, by titration of each of the ligands with TBAOH. We also studied the reverse protonation of the fluorophores using TFA. The structural and electronic properties of the neutral and the deprotonated forms of the fluorophores were also examined in the framework of DFT calculations. Also, the cytotoxicity of each of the compounds was tested against L929 fibroblasts and human lung cancer (small cell). Furthermore, the antimicrobial activity of each of the compounds was studied against both Gram-negative and Gram-positive bacterial and fungal species. In the final studies, the plasmid DNA interactions with the compounds were investigated with agarose gel electrophoresis. The thermal properties of all the prepared compounds were determined by thermal gravimetric analysis (TGA) and were found to be thermostable up to at least 335 degrees C.en_US
dc.description.sponsorshipGazi UniversityGazi Universityen_US
dc.description.sponsorshipThis work was supported by Gazi University. The numerical calculations reported in this paper were fully performed at TUBITAK ULAKBIM, High Performance and Grid Computing Center (TRUBA resources). The authors are grateful to Prof. Dr. Mehmet Sayim Karacan for giving us access to his lab and the fluorescent spectrometer.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jphotochem.2018.09.041
dc.identifier.endpage306en_US
dc.identifier.issn1010-6030
dc.identifier.scopus2-s2.0-85054846644
dc.identifier.scopusqualityQ1
dc.identifier.startpage296en_US
dc.identifier.urihttps://doi.org/10.1016/j.jphotochem.2018.09.041
dc.identifier.urihttps://hdl.handle.net/20.500.12587/8002
dc.identifier.volume368en_US
dc.identifier.wosWOS:000452575600037
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal Of Photochemistry And Photobiology A-Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoumarin-thiopheneen_US
dc.subjectSchiff basesen_US
dc.subjectEffects of substituentsen_US
dc.subjectPhotophysical propertiesen_US
dc.subjectDFT calculationsen_US
dc.subjectBiological activityen_US
dc.titleNovel fluorescent coumarin-thiophene-derived Schiff bases: Synthesis, effects of substituents, photophysical properties, DFT calculations, and biological activitiesen_US
dc.typeArticle

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