The relationship between mutation carriage of BRCA1/2 and clinicopathological characteristics in women with breast cancer – experience from a diagnostic centre in Turkey

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dc.contributor.authorDuzkale, Neslihan
dc.contributor.authorGuler, Onur Can
dc.contributor.authorKutun, Suat
dc.contributor.authorEmiroglu, Canan
dc.contributor.authorSaridemir, Serdar
dc.contributor.authorGokce, Aysun
dc.contributor.authorKandemir, Olcay
dc.date.accessioned2025-01-21T16:28:57Z
dc.date.available2025-01-21T16:28:57Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe 5–10% of breast cancers (BC) are hereditary, and BRCA1/2 are causative in 25% of those inherited. It was aimed to examine the BRCA1/2 genotype-BC phenotype relationship. In 170 female patients with BC, BRCA1/2 genes were investigated using Next Generation Sequencing. Demographic and clinicopathological characteristics of the patients and correlations of pedigree analysis with BRCA1/2 mutation status were analysed. BRCA1/2 carriage was found to be 9.4%. When the patients were grouped as ? 40 and > 40 according to the age at diagnosis of BC, the tumour grade was higher in the ? 40 groups. In the study, BRCA1/2 carriage and tumour grade were higher in patients with triple-negative breast cancers (TNBC). The risk of TNBC was 5.560 times higher in BRCA1/2 carriers than in non-carriers. There is a significant relationship between BRCA1/2 carrier and BC hormone receptor negativity, tumour grade, and BC diagnosis age. © 2024, Termedia Publishing House Ltd.. All rights reserved.
dc.identifier.doi10.5114/pjp.2024.142750
dc.identifier.endpage204
dc.identifier.issn1233-9687
dc.identifier.issue3
dc.identifier.pmid39451174
dc.identifier.scopus2-s2.0-85207363324
dc.identifier.scopusqualityQ4
dc.identifier.startpage192
dc.identifier.urihttps://doi.org/10.5114/pjp.2024.142750
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23658
dc.identifier.volume75
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd.
dc.relation.ispartofPolish Journal of Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectBRCA1; BRCA2; breast cancer; oestrogen receptor; progesterone receptor; triple-negative
dc.titleThe relationship between mutation carriage of BRCA1/2 and clinicopathological characteristics in women with breast cancer – experience from a diagnostic centre in Turkey
dc.typeArticle

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