Involvement of cholinoceptors in cadmium-induced endothelial dysfunction

Basit Öğe Kaydı
dc.contributor.authorBilgen, İbrahim
dc.contributor.authorÖner. Gülşen
dc.contributor.authorCirrik, Selma
dc.contributor.authorEdremitlioglu, Mustafa
dc.contributor.authorAlkan, Zeliha
dc.date.accessioned2020-06-25T15:13:20Z
dc.date.available2020-06-25T15:13:20Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description.abstractCadmium (Cd) toxicity was produced in male rats to study the role of cholinoceptors in Cd-induced endothelial dysfunction. The changes in the tension of the aortic rings to constrictor and dilator agonists were compared with those of controls. A Cd-induced significant increase in phenylephrine response was associated with a decrease in basal dilator prostanoid release. In Cd-exposed rings, despite an obvious depression in the acetylcholine (ACh) response, the receptor-independent dilation to the calcium ionophore A23187, which elicits a receptor-independent endothelial relaxation, was slightly elevated (p< 0.01), but the smooth muscle cell response to the NO donor, sodium nitroprusside (SNP) remained unaltered. Cadmium decreased both the maximal response to ACh (10-5M) and its pirenzepine (Prz) sensitive component. The M1 type cholinoceptor-mediated response to ACh decreased in Cd-exposed rings to 10.30 ± 5.00% from 38.40 ± 6.90% (p< 0.001). Cadmium also reduced the share of indomethacin 1.64% to 13.92 ± 2.89% (p< 0.01), which correlated well with the changes in the M1-mediated response (r= 0.991, p < 0.0001). Most of the deleterious effect of Cd appears to Abbreviations: Cd = Cadmium, ACh = Acetylcholine, PG12= Prostacyclin, Indo = Indomethacin, L-NAME = N (G)-nitro-L-arginine methyl ester, EDHF = Endothelium-derived hyperpolarizing factor, Galla = Gallamine, PE = Phenylephrine, Prz = Pirenzepine, Atr = Atropine be restricted to the M1-dependent ACh response. These findings suggest that Cd produces an endothelial dysfunction by impairing the Ml type cholinoceptor mediated response, which seems to be involved in prostanoid release. © 2011, by Walter de Gruyter GmbH & Co. All rights reserved.en_US
dc.description.sponsorshipAkdeniz Üniversitesien_US
dc.description.sponsorshipThis study was partially supported by Akdeniz Universityen_US
dc.description.sponsorshipResearch Foundation (Grant number 96.03.0103.03).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1515/JBCPP.2003.14.1.55
dc.identifier.endpage76en_US
dc.identifier.issn07926855
dc.identifier.issue1en_US
dc.identifier.pmid12901446
dc.identifier.scopus2-s2.0-0141883957
dc.identifier.scopusqualityQ3
dc.identifier.startpage55en_US
dc.identifier.urihttps://doi.org/10.1515/JBCPP.2003.14.1.55
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1745
dc.identifier.volume14en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofJournal of Basic and Clinical Physiology and Pharmacology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmuscarinic receptorsen_US
dc.subjectnitric oxideen_US
dc.subjectprostaglandinen_US
dc.subjectprostanoid releaseen_US
dc.titleInvolvement of cholinoceptors in cadmium-induced endothelial dysfunctionen_US
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu