Sezaryen ile doğum sonrası ağrıda deksketoprofen trometamolün analjezik etkisinin lornoksikam ve plasebo ile karşılaştırılması
Yükleniyor...
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Sezaryenle doğum sonrası ağrıda deksketoprofen trometamolün analjezik etkisinin lornoksikam ve plasebo ile karşılaştırılması amaçlandı. Yöntem: Elektif sezaryen operasyonu planlanan 90 hasta randomize olarak üç eşit gruba ayrıldı. Hastalara cerrahi kesinin kapatılmasından önce intravenöz olarak 50 mg deksketoprofen trometamol (Grup D), 8 mg lornoksikam (Grup L) veya %0,9 NaCl (Grup P) verildi. Cerrahi sonrası tüm hastalara hasta kontrollü analjezi cihazı ile intravenöz tramadol verildi (bolus doz: 20 mg, kilit süresi: 10 dakika). Postoperatif ağrı vizüel analog skala (VAS) ile değerlendirildi. VAS 3 olduğunda ek doz (20 mg, i.v.) tramadol verildi. İlk analjezik ihtiyacı zamanı, postoperatif 1, 3, 6, 12, 24. saatlerde VAS değerleri, ek analjezik tramadol dozları, toplam tramadol tüketimi miktarı, hasta memnuniyeti, istenmeyen etkiler kaydedildi. Bulgular: Grup D ve Grup L karşılaştırıldığında, ilk analjezik ihtiyacının ortaya çıkış süresi Grup D için belirgin olarak uzun (p 0,01) ve postoperatif ilk bir saatte VAS değerleri Grup D için belirgin olarak daha düşüktü (p 0,007). Toplam tramadol tüketimi miktarı ve hasta memnuniyeti her iki grupta benzerdi. Ek analjezik gereksinimi postoperatif 1. saatte Grup D'de Grup P ve Grup L’ye göre daha azdı (sırasıyla; p 0,001 ve p 0,01). Postoperatif ilk 24 saat sonunda toplam ek analjezik gereksinimi Grup D’de Grup P ve Grup L’ye göre istatistiksel olarak anlamlı derecede daha azdı (sırasıyla; p 0,001, p 0,006). Sonuç: Postoperatif erken dönemde deksketoprofen trometamol daha uzun ilk analjezik ihtiyacı ortaya çıkış süresi, daha düşük ek analjezik ihtiyacı miktarı ve postoperatif ilk bir saatte daha düşük VAS değerleri ile postoperatif ağrının giderilmesinde lornoksikama göre daha etkin bulundu.
Objective: The aim was to compare the effect of dexketoprofen trometamol with lornoxicam and placebo on post-cesarean delivery pain. Method: Ninety patients scheduled for cesarean-section under spinal anesthesia were randomized equally into three groups. Before the surgical incision closure, 50 mg dexketoprofen trometamol (Group D), 8 mg lornoxicam (Group L) or 0.9% NaCl (Group P) was given intravenously. After the surgery all patients received intravenous tramadol via patient controlled analgesia device (bolus dose: 20 mg, lock out: 10 min.). Postoperative pain was assessed by visual analog scale (VAS). Additional analgesic doses of tramadol (20 mg, i.v) were given when the VAS value was ≥ 3. The time of the first analgesic requirement, VAS values at the 1, 3, 6, 12, 24 hours of the postoperative period, additional analgesic doses of tramadol, cumulative tramadol consumption, patient satisfaction, adverse effects of drugs were recorded. Results: The time of the first analgesic requirement was significantly longer and the VAS values at the postoperative first hour was significantly lower in the Group D than the Group L (p 0.01, p 0.007; respectively). The cumulative tramadol consumption and patient satisfaction was similar between the Group D and Group L. The additional analgesic consumption at postoperative first hour was significantly lower in the Group D when compared to Group L and Group P (p 0.01, p< 0.001; respectively). The total additional analgesic consumption at the end of the postoperative 24 hours was lower in the Group D when compared to Group P and Group L (p 0.01, p< 0.001; respectively). Conclusion: Dexketoprofen trometamol had more analgesic efficacy for postoperative pain at early postoperative period with prolonged first analgesic requirement time, decreased additional analgesic requirement, decreased VAS values in the first postoperative hour, when compared with lornoxicam.
Objective: The aim was to compare the effect of dexketoprofen trometamol with lornoxicam and placebo on post-cesarean delivery pain. Method: Ninety patients scheduled for cesarean-section under spinal anesthesia were randomized equally into three groups. Before the surgical incision closure, 50 mg dexketoprofen trometamol (Group D), 8 mg lornoxicam (Group L) or 0.9% NaCl (Group P) was given intravenously. After the surgery all patients received intravenous tramadol via patient controlled analgesia device (bolus dose: 20 mg, lock out: 10 min.). Postoperative pain was assessed by visual analog scale (VAS). Additional analgesic doses of tramadol (20 mg, i.v) were given when the VAS value was ≥ 3. The time of the first analgesic requirement, VAS values at the 1, 3, 6, 12, 24 hours of the postoperative period, additional analgesic doses of tramadol, cumulative tramadol consumption, patient satisfaction, adverse effects of drugs were recorded. Results: The time of the first analgesic requirement was significantly longer and the VAS values at the postoperative first hour was significantly lower in the Group D than the Group L (p 0.01, p 0.007; respectively). The cumulative tramadol consumption and patient satisfaction was similar between the Group D and Group L. The additional analgesic consumption at postoperative first hour was significantly lower in the Group D when compared to Group L and Group P (p 0.01, p< 0.001; respectively). The total additional analgesic consumption at the end of the postoperative 24 hours was lower in the Group D when compared to Group P and Group L (p 0.01, p< 0.001; respectively). Conclusion: Dexketoprofen trometamol had more analgesic efficacy for postoperative pain at early postoperative period with prolonged first analgesic requirement time, decreased additional analgesic requirement, decreased VAS values in the first postoperative hour, when compared with lornoxicam.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Anestezi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
20
Sayı
2
Künye
Aykaç, E., Büyükkoçak, Ü., Köse, E., Sağsöz, N. (2012). Sezaryen ile doğum sonrası ağrıda deksketoprofen trometamolün analjezik etkisinin lornoksikam ve plasebo ile karşılaştırılması. Anestezi Dergisi, 20(2), 80 - 85.
