Is there a relationship between serum kisspeptin levels and endometrial polyps in women with premenopausal status
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Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Endometrial polyps are frequently associated with abnormal uterine bleeding. The kispeptin family is one of the peptidesthat play a role in reproductive functions and whose expression varies in various uterine pathologies. The aim of the study was todetermine the relationship between serum Kisspeptin levels and endometrial polyps in women with premenopausal status.Material and Methods: The blood was collected prior to endometrial sampling from women admitted to the hospital due to abnormaluterine bleeding. According to the pathology results, patients were identified as polyp group (n38) (endometrial polyps) and controlgroup (n50) (normal endometrial findings). Kisspeptin-54 levels were determined by ELISA method from serum obtained fromvenous blood.Results: There were no difference was found between the patients’ age, body mass index, gravida, para, abortus and the numberof living children were compared (p0.05). There was no statistically significant difference between the groups in terms of folliclestimulating hormone, luteinizing hormone and thyroid stimulating hormone values (p0.05). Plasma kisspeptin (1.840.93 ng/dLand 1.320.47 ng/dL, p 0.008) and estradiol (90.3413.02 pg/mL and 81.7512.36 pg/mL, p0.002) levels were significantly higherin the polyp group than in the control group. After the Receiver Operating Characteristic (ROC) analysis the area under the curve(AUC) was 1.26 (p 0.08), (95% CI, 0.550-0.782). The sensitivity value was 0.684 (0.512-0.819), the specificity was 0.620 (0.471-0.750).Conclusion: The serum Kisspeptin-54 and estradiol levels were found higher in patients with endometrial polyps.
Açıklama
Anahtar Kelimeler
Biyoloji, Diş Hekimliği, Alerji, Anatomi ve Morfoloji, Androloji, Anestezi, Odyoloji ve Konuşma-Dil Patolojisi, Biyokimya ve Moleküler Biyoloji, Biyofizik, Biyoteknoloji ve Uygulamalı Mikrobiyoloji, Kalp ve Kalp Damar Sistemi, Hücre Biyolojisi, Klinik Nöroloji, Yoğun Bakım, Tıp, Dermatoloji, Acil Tıp, Endokrinoloji ve Metabolizma, Gastroenteroloji ve Hepatoloji, Geriatri ve Gerontoloji, Sağlık Bilimleri ve Hizmetleri, Hematoloji, İmmünoloji, Enfeksiyon Hastalıkları, Tamamlayıcı ve Entegre Tıp, Tıbbi Etik, Tıbbi İnformatik, Tıbbi Laboratuar Teknolojisi, Genel ve Dahili Tıp, Adli Tıp, Tıbbi Araştırmalar Deneysel, Mikrobiyoloji, Nörolojik Bilimler, Kadın Hastalıkları ve Doğum, Onkoloji, Göz Hastalıkları, Ortopedi, Kulak, Burun, Boğaz, Patoloji, Pediatri, Periferik Damar Hastalıkları, Fizyoloji, Temel Sağlık Hizmetleri, Psikiyatri, Halk ve Çevre Sağlığı, Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme, Rehabilitasyon, Solunum Sistemi, Romatoloji, Spor Bilimleri, Cerrahi, Transplantasyon, Tropik Tıp, Üroloji ve Nefroloji, Farmakoloji ve Eczacılık, Toksikoloji
Kaynak
Annals of Medical Research
WoS Q Değeri
Scopus Q Değeri
Cilt
26
Sayı
7
Künye
Yıldırım, E., Derici, M. K., Şimşek, O. Y., Demir, E. (2019). Is there a relationship between serum kisspeptin levels and endometrial polyps in women with premenopausal status. Annals of Medical Research, 26(7), 1253 - 1257.
