Does aspartate aminotransferase to alanine aminotransferase ratio predict acute kidney injury after cardiac surgery?

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dc.contributor.authorYıldırım, Gültekin
dc.contributor.authorAli, Bolat
dc.contributor.authorHatice, Keles
dc.contributor.authorAtike, Tekeli Kunt
dc.date.accessioned2025-01-21T16:27:19Z
dc.date.available2025-01-21T16:27:19Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AST/ALT) frequently is used in the diagnosis and prognosis of liver diseases, however it is also used in the diagnosis and prognosis of many other diseases, such as myocardial infarction, acute ischemic stroke, and peripheral artery disease. Acute kidney injury (AKI) is one of the most important complications after cardiac surgery and is one of the main causes of morbidity and mortality. The purpose of the study was to analyze the relationship between AST to ALT and AKI after isolated coronary artery bypass graft surgery (CABG). Methods: We retrospectively reviewed the prospectively collected data of 253 adult patients, who underwent isolated CABG surgery with normal renal function (baseline serum creatinine value <1.4 mg/dL). Preoperative (T0) and postoperative day 1 and day 3 (T1 and T2) serum AST and ALT levels were analyzed, and AST/ALT was calculated. A preoperative AST/ALT of 1.22 was found to be the best cutoff point for predicting postoperative AKI. Kidney injury was interpreted, according to RIFLE classification. The effect of AST to ALT ratio on AKI after CABG was determined using logistic regression analysis, and the results were expressed as odds ratio (OR) with a 95% confidence interval (CI). A P value < .05 was considered statistically significant. Results: Postoperative AKI occurred in 40 patients (15.8%). On logistic regression analysis, higher AST/ALT both preoperatively and postoperatively were associated with an increased incidence of postoperative AKI (T0: OR, 3.983; 95% CI, 1.940-8.180, P < .001, T1: OR, 2.760; 95% CI, 1.381-5.515, P = .004, T2: OR, 2.515; 95% CI, 1.195-5.294, P = .015). Conclusion: Preoperative and postoperative elevated AST to ALT ratio seems to be associated with an increased incidence of AKI after elective isolated CABG surgery. © 2021 Forum Multimedia Publishing LLC. All rights reserved.
dc.identifier.doi10.1532/hsf.3849
dc.identifier.endpageE511
dc.identifier.issn1098-3511
dc.identifier.issue30
dc.identifier.pmid34173741
dc.identifier.scopus2-s2.0-85108796182
dc.identifier.scopusqualityQ3
dc.identifier.startpageE506
dc.identifier.urihttps://doi.org/10.1532/hsf.3849
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23320
dc.identifier.volume24
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherForum Multimedia Publishing LLC
dc.relation.ispartofHeart Surgery Forum
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAcute Kidney Injury; Alanine Transaminase; Aspartate Aminotransferases; Cardiac Surgical Procedures; Coronary Artery Bypass; Female; Humans; Incidence; Male; Middle Aged; Postoperative Complications; Prognosis; Retrospective Studies; Risk Factors; Turkey; alanine aminotransferase; aspartate aminotransferase; creatinine; alanine aminotransferase; aspartate aminotransferase; acute kidney failure; adult; aminotransferase blood level; analytical parameters; Article; aspartate aminotransferase blood level; aspartate aminotransferase to alanine aminotransferase ratio; controlled study; coronary artery bypass graft; creatinine blood level; disease association; female; health care cost; heart surgery; hospitalization; human; incidence; kidney function; major clinical study; male; medical record review; middle aged; mortality rate; postoperative period; preoperative evaluation; retrospective study; Risk, Injury, Failure, Loss of kidney function and End-stage kidney disease classification; acute kidney failure; adverse event; blood; enzymology; heart surgery; postoperative complication; prognosis; risk factor; turkey (bird)
dc.titleDoes aspartate aminotransferase to alanine aminotransferase ratio predict acute kidney injury after cardiac surgery?
dc.typeArticle

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