Elevated neutrophil-lymphocyte ratio in patients with euthyroid chronic autoimmune thyreotidis

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dc.contributor.authorKeskin H.
dc.contributor.authorKaya Y.
dc.contributor.authorCadirci K.
dc.contributor.authorKucur C.
dc.contributor.authorZiypak E.
dc.contributor.authorSimsek E.
dc.contributor.authorCarlioglu A.
dc.date.accessioned2020-06-25T15:17:41Z
dc.date.available2020-06-25T15:17:41Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective. Th e neutrophil-lymphocyte ratio (NLR), determined from peripheral blood, is accepted as an available and practical indicator of the systemic infl ammation. In this study, we aimed to determine whether the NLR was higher in euthyroid chronic autoimmune thyreotidis (CAT) patients compared to a healthy control group. Methods. A total of 112 patients were enrolled in this study, including 59 patients with euthyroid CAT on any form of therapy and 53 healthy controls. Th e CAT patients were similar in age to the healthy control group (mean 33.9±12.8 years versus 30.2±12.4 years, p=0.10). Measurements were available for the white blood cells (WBC), neutrophils, lymphocytes, platelets, C-reactive protein (CRP), thyroid peroxidase immune antibody (anti-TPO), and anti-thyroglobulin immune antibody (anti-TG). Th e NLR and platelet-lymphocyte ratio (PLR) were calculated. Diff erences between the CAT and control groups were tested using the student’s t-test and the correlations were determined using Pearson’s correlation coefficients. Results. Th ere were no diff erences between the CAT and control groups for WBCs (7.9±0.3 and 7.4±0.2, respectively; p=0.1) or neutrophils (5.5±0.3 and 5.4±1.1; p=0.9), but lymphocytes were higher in the CAT group (3.1±0.5 vs. 2.04±0.1; p=0.05) as was the NLR (4.0±0.7 vs. 2.0±0.1; p=0.01). Th e NLR was positively correlated with CRP (r=0.6, p<0.001), anti-TPO (r=0.3, p<0.001), anti-TG (r=0.3, p=0.006), WBCs (r=0.4, p<0.001), and the PLR (r=0.73, p<0.001). Th e PLR was also higher in the CAT than the control group (p=0.02). Conclusions. In this study, we found that NLR values were higher in euthyroid CAT patients than in a healthy control group and that NLR correlated with autoantibodies used to diagnose the disease. © 2016, Institute of Experimental Endocrinology. All rights reserved.en_US
dc.identifier.doi10.1515/enr-2016-0017
dc.identifier.endpage153en_US
dc.identifier.issn12100668
dc.identifier.issue3en_US
dc.identifier.pmid27560798
dc.identifier.scopus2-s2.0-84983423089
dc.identifier.scopusqualityQ3
dc.identifier.startpage148en_US
dc.identifier.urihttps://doi.org/10.1515/enr-2016-0017
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2487
dc.identifier.volume50en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInstitute of Experimental Endocrinologyen_US
dc.relation.ispartofEndocrine Regulations
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEuthyroid chronic autoimmune thyreotidisen_US
dc.subjectInflammationen_US
dc.subjectNeutrophil-lymphocyte ratioen_US
dc.titleElevated neutrophil-lymphocyte ratio in patients with euthyroid chronic autoimmune thyreotidisen_US
dc.typeArticle

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