Immunologic abnormalities and surgical experiences in recurrent facial nerve paralysis

dc.contributor.authorYetiser, S.
dc.contributor.authorSatar, B.
dc.contributor.authorKazkayasi, M.
dc.date.accessioned2020-06-25T17:34:59Z
dc.date.available2020-06-25T17:34:59Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: To document immunologic findings in patients with recurrent facial paralysis (RFP) and to compare the results of the surgery with the results of medical treatment. Study Design: Retrospective case review. Setting: Tertiary care referral center. Patients: Nine patients with RFP were reviewed. Intervention: Patients underwent nonspecific antibody detection, protein electrophoresis (in blood and cerebrospinal fluid [CSF]) and oligoclonal band determination for immunoglobulin G, A, and M (in CSF). The extended subtotal facial nerve decompression via the transmastoid and transattic route was performed in four patients. Five patients received medical treatment only (steroids, vitamin 13). Results: Two patients had the complete and four patients had the oligosymptomatic form of Melkersson-Rosenthal syndrome. The other three patients were diagnosed with idiopathic RFP. Serum immunoglobulin G was high in seven of nine patients (77%). CSF protein electrophoresis demonstrated an elevated albumin fraction in six of nine patients (66%). CSF immunoglobulin G was high in four of nine patients (44%). The oligoclonal band in CSF was negative in all patients. Mean follow-up time was 5.2 +/- 2.6 years and 3 +/- 1.5 years for surgically treated patients and medically treated patients, respectively. None of the patients who underwent the surgery demonstrated recurrence. Although marked recovery was observed in patients who had received medical treatment, three of them had recurrence during the follow-up period. Conclusion: Serologic test results have demonstrated immune system involvement in cases of idiopathic RFP and in cases of Melkersson-Rosenthal syndrome, providing no distinction between the two. There was no sign substantiating local antibody production in CSF, which implies that the elevated antibodies in CSF were peripheral in origin. Although the serologic test results were not conclusive for a specific diagnosis, they support an immune-mediated pathogenesis. Despite the small number of patients who underwent the extended transmastoid facial nerve decompression, our follow-up data were suggestive for the prevention of recurrences.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/00129492-200209000-00027
dc.identifier.endpage778en_US
dc.identifier.issn1531-7129
dc.identifier.issn1537-4505
dc.identifier.issue5en_US
dc.identifier.pmid12218633
dc.identifier.startpage772en_US
dc.identifier.urihttps://doi.org/10.1097/00129492-200209000-00027
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2980
dc.identifier.volume23en_US
dc.identifier.wosWOS:000177918000028
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofOtology & Neurotology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectextended subtotal decompression of the facial nerveen_US
dc.subjectimmune-mediated diseaseen_US
dc.subjectMelkersson-Rosenthal syndromeen_US
dc.subjectrecurrent facial paralysisen_US
dc.titleImmunologic abnormalities and surgical experiences in recurrent facial nerve paralysisen_US
dc.typeArticle

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