Electrospun nanofiber drug delivery systems and recent applications: An overview

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dc.authoridAKDAG, YAGMUR/0000-0003-4139-9815
dc.contributor.authorMuratoglu, Semsi
dc.contributor.authorInal, Murat
dc.contributor.authorAkdag, Yagmur
dc.contributor.authorGulsun, Tugba
dc.contributor.authorSahin, Selma
dc.date.accessioned2025-01-21T16:38:29Z
dc.date.available2025-01-21T16:38:29Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractFiber technology plays a significant role in advancing drug research. While developing drug delivery systems, nanofiber technology has gained importance due to its high surface area to volume ratio and porosity. The most preferred nanofiber production method is the electrospinning method. This review focuses on electrospun nanofiber drug delivery systems, including analysis of critical process parameters affecting electrospinning and nanofiber properties. Moreover, the design strategies for nanofiber drug delivery systems are explored, including equipment preferences and design types. Given to these design strategies, it is possible to design either nanofiber mat or nanofiber itself. It has been shown that a tailor-made drug delivery system can be prepared using axialbased nozzles and other equipment options. In addition, the prominent features and usage areas of frequently used polymers are mentioned. General characterization studies of post-production nanofibers are discussed. Examples of areas of use for pharmaceutical purposes are presented. Finally, drug release kinetics were evaluated on electrospun nanofiber drug delivery systems. As a result of exhaustive evaluations, various effective applications in the literature have been shown to achieve remarkable results such as drug release manipulation, drug targeting, self-assembling formulation strategies. Therefore, it is clear that in the field of electrospun nanofiber technology, it is possible to modify all the process options and develop a unique drug delivery product, thanks to a comprehensive evaluation of the critical quality parameters of the drug product.
dc.identifier.doi10.1016/j.jddst.2024.105342
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85182014200
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2024.105342
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24676
dc.identifier.volume92
dc.identifier.wosWOS:001164441800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectDrug delivery; Drug release; Electrospinning; Nanofiber; Process parameters
dc.titleElectrospun nanofiber drug delivery systems and recent applications: An overview
dc.typeArticle

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