Myelosuppression and Oxidative Stress Induced by Cyclophosphamide in Rats: The Protective Role of Selenium

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dc.contributor.authorAyhanci, Adnan
dc.contributor.authorHeybeli, Nilhan
dc.contributor.authorKulcanay Şahin, İlknur
dc.contributor.authorCengiz, Mustafa
dc.date.accessioned2025-01-21T16:28:04Z
dc.date.available2025-01-21T16:28:04Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim of this study is to detect the protective role of selenium (Se) against bone marrow and blood toxicity in CP-induced hematoxicity model. We categorized the rats into 6 groups of 7 animals in each group (control; 150 mg/kg CP; 0.5 mg/kg Se; 1 mg/kg Se; 150+0.5 mg/kg CP+Se; 150+1 mg/kg CP+Se). Se injections started 5 days before the CP injections and carried on until the end of the experiment (6th day) for the groups to which CP was injected together with Se. CP was applied as a single dose before anesthesia. For that reason, on the 7th day, blood was taken with cardiac puncture and bone marrow was taken by flushing the femur. Peripheral blood cells and bone marrow nucleated cells were counted on a cell counter. Intraperitoneal CP injection was found to reduce the number of leukocytes by 317%, thrombocyte by 36% and bone marrow nucleated cells by 481% compared to the control group. In the groups where CP was given after 0.5 and 1 mg/kg Se, numbers of leukocyte, thrombocyte and bone marrow nucleated cells were considerably improved compared to the group to which CP was given only (p<0.001). Results show that 1 mg/kg Se has a better protection than 0.5 mg/kg against CP associated hematoxicity and myelosuppression. Our results also imply that the doses of Se could be adjusted according to enhance in CP dose so as to gain a stronger protective effect. We believe there is a need of further studies in which different doses of Se will be used against CP induced hematoxicity. Se can provide protection against CP-induced myelosupression and lipid peroxidation. © 2019, Adiyaman University. All rights reserved.
dc.identifier.doi10.37094/adyujsci.617016
dc.identifier.endpage265
dc.identifier.issn2147-1630
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85125604095
dc.identifier.scopusqualityQ3
dc.identifier.startpage252
dc.identifier.trdizinid430137
dc.identifier.urihttps://doi.org/10.37094/adyujsci.617016
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/430137
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23472
dc.identifier.volume9
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAdiyaman University
dc.relation.ispartofAdiyaman University Journal of Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectCyclophosphamide; Hematoxicity; Lipid peroxidation; Myelosupression; Selenium
dc.titleMyelosuppression and Oxidative Stress Induced by Cyclophosphamide in Rats: The Protective Role of Selenium
dc.title.alternativeSıçanlarda Siklofosfamid'in Neden Olduğu Miyelosupresyon ve Oksidatif Stres: Selenyumun Koruyucu Rolü
dc.typeArticle

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