Contribution of Bone Marrow–Derived Mesenchymal Stem Cells to Healing of Pulmonary Contusion-Created Rats

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dc.contributor.authorDemir, Sabri
dc.contributor.authorErturk, Ahmet
dc.contributor.authorGunal, Yasemin Dere
dc.contributor.authorOzmen, Ismail
dc.contributor.authorZengin, Mehmet
dc.contributor.authorYildiz, Dincer
dc.contributor.authorKaraoz, Erdal
dc.date.accessioned2025-01-21T16:27:10Z
dc.date.available2025-01-21T16:27:10Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: The most common thoracic injury in children, resulting in trauma, is pulmonary contusion (PC). Bone marrow–derived mesenchymal stem cells (BM-MSCs) are used in wound healing and many other diseases. This study aims to examine the effects of BM-MSCs on PC healing in rats. Materials and methods: A total of 45 male Wistar albino rats were used. Four groups were formed. BM-MSCs were labeled with the green fluorescent protein. PC was observed in the control group. In group II, PC occured and left to spontaneous healing. In group III, PC formed and BM-MSCs were given. In group IV, BM-MSCs were given without PC formation. Subjects were sacrificed 1 week later. Whether there was any difference in terms of BM-MSC involvement and lung injury score was investigated. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS), version 17.0, software (SPSS Inc., Chicago, IL), and p value of <0.05 was considered statistically significant. Results: BM-MSCs were collected much more in the lungs in group III than in group IV. Group III had a lower lung injury score value than group II. Conclusion: The greater involvement of the BM-MSCs in the injury site, and further reductions in lung injury score suggest that BM-MSCs are contributing to the healing of the injury. The use of BM-MSCs in risky patients with diffuse PC may be an alternative treatment to conventional methods. © 2020 Elsevier Inc.
dc.description.sponsorshipKirikkale University; SRPCU-KU
dc.identifier.doi10.1016/j.jss.2020.12.006
dc.identifier.endpage214
dc.identifier.issn0022-4804
dc.identifier.pmid33450629
dc.identifier.scopus2-s2.0-85099132758
dc.identifier.scopusqualityQ1
dc.identifier.startpage205
dc.identifier.urihttps://doi.org/10.1016/j.jss.2020.12.006
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23283
dc.identifier.volume261
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.relation.ispartofJournal of Surgical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectBone marrow-derived mesenchymal stem cells; Children; Pulmonary contusion; Thoracic injury; Trauma
dc.titleContribution of Bone Marrow–Derived Mesenchymal Stem Cells to Healing of Pulmonary Contusion-Created Rats
dc.typeArticle

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