Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats

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dc.contributor.authorDikmen, Nursel
dc.contributor.authorCellat, Mustafa
dc.contributor.authorEtyemez, Muhammed
dc.contributor.authorİşler, Cafer Tayer
dc.contributor.authorUyar, Ahmet
dc.contributor.authorAydın, Tuba
dc.contributor.authorGüvenç, Mehmet
dc.date.accessioned2025-01-21T16:26:47Z
dc.date.available2025-01-21T16:26:47Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAcute lung injury (ALI) is one of the most common causes of death in diseases with septic shock. Oleuropein, one of the important components of olive leaf, has antioxidant and anti-inflammatory effects. The objective of this study was to investigate the effects of oleuropein on lipopolysaccharide (LPS)-induced ALI in rats. Oleuropein was administered to rats at a dose of 200 mg/kg for 20 days and LPS was given through intratracheal administration to induce ALI. The study was terminated after 12 h. The results showed that in the group treated with oleuropein, inflammatory cytokines and oxidative stress decreased in serum, bronchoalveolar lavage fluid (BALF), and lung tissue, and there were significant improvements in the picture of acute interstitial pneumonia (AIP) caused by LPS in histopathological examination. Based on the findings of the present study, oleuropein showed protective effects against LPS-induced ALI. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
dc.description.sponsorshipHatay Mustafa Kemal University; Mustafa Kemal Üniversitesi, (20.M.020)
dc.identifier.doi10.1007/s10753-021-01496-x
dc.identifier.endpage2259
dc.identifier.issn0360-3997
dc.identifier.issue6
dc.identifier.pmid34515957
dc.identifier.scopus2-s2.0-85114770783
dc.identifier.scopusqualityQ1
dc.identifier.startpage2246
dc.identifier.urihttps://doi.org/10.1007/s10753-021-01496-x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23201
dc.identifier.volume44
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectlipopolysaccharide; lung injury; oleuropein
dc.titleAmeliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats
dc.typeArticle

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