Synthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands

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dc.contributor.authorErtuğrul, Emine Merve
dc.contributor.authorÖzçelik, Azime Berna
dc.contributor.authorÇerçi, Nebahat Aytuna
dc.contributor.authorAçık, Leyla
dc.contributor.authorUtku, Semra
dc.date.accessioned2025-01-21T16:33:53Z
dc.date.available2025-01-21T16:33:53Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground and Aims: Cisplatin is currently one of the most widely used anticancer drugs in the world. However, its clinical usefulness has frequently been limited by severe side effects, such as nephrotoxicity, ototoxicity and neurotoxicity. Therefore, platinum(II) oxalato complexes with substitute imidazole or benzimidazole carrier ligands were synthesized and their cytotoxic effects were investigated against non-small cell lung cancer (H1299) and human colon adenocarcinoma (CaCo-2), and mouse fibroblast cells lines (L929).Methods: Four platinum(II) complexes, [Pt(L1-L4)2(oxalate)] were synthesized and characterized by FT-IR, 1H NMR and elemental analyses. The MTT method was used to determine the potential antiproliferative effect of synthesized platinum(II) complexes and positive controls.Results: In this study, the cytotoxic activity of platinum(II) complexes against tested cell lines was assessed, with moderate IC50 values. According to IC50 values, Complex 5 with 2-ethylbenzimidazole ligand was found to be the most active complex against H1299 and CaCo-2 cell lines. In general, the compounds are also promising drug candidates for H1299 cell lines with very low activity against the CaCo-2 cell lines.Conclusion: Further modification and development of Complex 4 and 5 derivatives and in vitro cytotoxic activity studies against different cancer cell lines may lead to the emergence of new anticancer agents in the near future.
dc.description.sponsorshipMersin University Scientific Research Fund [2018-1-TP2-2783]
dc.description.sponsorshipFinancial Disclosure: This study was carried out with fund-ing support from Mersin University Scientific Research Fund project numbered 2018-1-TP2-2783.
dc.identifier.doi10.26650/IstanbulJPharm.2023.1266118
dc.identifier.endpage313
dc.identifier.issn2587-2087
dc.identifier.issue3
dc.identifier.startpage308
dc.identifier.trdizinid1240033
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2023.1266118
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1240033
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23876
dc.identifier.volume53
dc.identifier.wosWOS:001136585600003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherIstanbul Univ, Fac Pharmacy
dc.relation.ispartofIstanbul Journal of Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectCytotoxic activity; 2-ethylbenzimidazole; 2-methylbenzimidazole; 2-phenylimidazole; platinum(II) complexes
dc.titleSynthesis, characterization and in vitro cytotoxic activity of platinum(II) oxalato complexes involving 2-substitutedimidazole or 2-substitutedbenzimidazole derivatives as carrier ligands
dc.typeArticle

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