Evaluation of putamen area and cerebral peduncle with surrounding cistern in patients with Parkinson's disease: is there a difference from controls in cranial MRI?

Simple item page
dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.contributor.authorSay, Bahar
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorInal, Mikail
dc.contributor.authorGoncuoglu, Alper
dc.contributor.authorYorubulut, Serap
dc.contributor.authorErgun, Ufuk
dc.date.accessioned2025-01-21T16:40:41Z
dc.date.available2025-01-21T16:40:41Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives Nigrostriatal dopaminergic neuron loss is essential in pathogenesis of Parkinson's disease (PD). The purpose of this study was to evaluate nigrostriatal structures including the putamen, cerebral peduncle, widths of interpeduncular cistern, and ambient cistern around the midbrain with conventional cranial magnetic resonance images (MRI) in patients with PD.Methods The MRI of 56 subjects was included, which was selected from the radiological data system for this retrospective study. The 29 patients with idiopathic PD were included and their disease duration, Hoehn&Yahr stage, and Levodopa equivalent dose (LED) were recorded. The 27 controls had a normal neurologic examination and cranial MRI. All subjects in the patient and control groups had right-hand dominance. Putamen and cerebral peduncle areas and widths of interpeduncular and ambient cisterns were measured in T2 sequences of MRI. Further statistical analysis was applied to exclude gender and age effect on areas.Results The areas of putamen and cerebral peduncles were significantly reduced in patients with PD compared to the control bilaterally (p < 0.001). Enlargement of interpeduncular and ambient cisterns in patients was higher than in controls, and it was significant (p < 0.001). A correlation was not observed between measurement results and clinical characteristics of patients with PD. Only the cerebral peduncle area/ambient cistern width ratio was significantly correlated with disease duration positively (right r = 0.46 p = 0.012, left r = 0.389 p = 0.037).Conclusion Clinicians should be careful with conventional MRIs of patients with idiopathic PD in practice. It may be different from controls without any neurological disorder, particularly putamen, cerebral peduncles, interpeduncular, and ambient cisterns.
dc.identifier.doi10.1080/01616412.2023.2281088
dc.identifier.endpage226
dc.identifier.issn0161-6412
dc.identifier.issn1743-1328
dc.identifier.issue3
dc.identifier.pmid37953510
dc.identifier.startpage220
dc.identifier.urihttps://doi.org/10.1080/01616412.2023.2281088
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24747
dc.identifier.volume46
dc.identifier.wosWOS:001104992100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNeurological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectParkinson's disease; MRI; basal ganglia; imaging; movement disorder; substantia nigra
dc.titleEvaluation of putamen area and cerebral peduncle with surrounding cistern in patients with Parkinson's disease: is there a difference from controls in cranial MRI?
dc.typeArticle

Files

Collections

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu

We collect and process your personal information for the following purposes: Authentication, Preferences, Acknowledgement and Statistics.
To learn more, please read our privacy policy.

Customize