Investigation the Cytotoxic and Anti-Proliferative Effects of Crude Venom of Euscorpius mingrelicus (Scorpiones: Euscorpiidae) Scorpion

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dc.contributor.authorKayhan, Nazife Yigit
dc.contributor.authorOcal, Ilkay Corak
dc.contributor.authorAkdeniz, Mustafa
dc.date.accessioned2025-01-21T16:28:00Z
dc.date.available2025-01-21T16:28:00Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Since they contain various toxins that may influence various biological events, scorpion venoms raise new hopes for cancer treatments. It is thought that the bioactive compounds contained in scorpion venom could be used in cancer treatments in near future. Materials and Methods: In this study, different cytotoxic, apoptotic, necrotic, and anti-proliferative effects of crude venom obtained from Euscorpius mingrelicus (Kessler, 1874) scorpions species were tested on human breast cancer cells (MCF-7), human lung carcinoma cells (H1299), and mice fibroblast cells (L929). Results: It was determined that the crude venom had cytotoxic and anti-proliferative effects on MCF-7 and fibroblast cells even when at low concentrations and the effect on H1299 was half of the effect on MCF-7 and fibroblast. It was observed that, as the dilution rate increased, the venom effect decreased, apoptosis and necrosis rates on H1299 decreased, and it had no effect on cell proliferation. With regards to the MCF-7 cells, apoptosis and necrosis rates were similar in H1299 cells. Conclusion: It was found that crude venom of E. mingrelicus scorpion played an effective role in decreasing the proliferation of MCF-7 cells, and more comprehensive studies are needed in order to determine the toxin that is responsible for this effect. © 2022 by the Author(s).
dc.identifier.doi10.26650/EurJBiol.2022.1105838
dc.identifier.endpage124
dc.identifier.issn2602-2575
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85146469901
dc.identifier.scopusqualityQ4
dc.identifier.startpage117
dc.identifier.trdizinid1173792
dc.identifier.urihttps://doi.org/10.26650/EurJBiol.2022.1105838
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1173792
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23442
dc.identifier.volume81
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherIstanbul University Press
dc.relation.ispartofEuropean Journal of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAnti-Proliferative; Apoptosis; Cancer; Necrosis; Scorpion Venom
dc.titleInvestigation the Cytotoxic and Anti-Proliferative Effects of Crude Venom of Euscorpius mingrelicus (Scorpiones: Euscorpiidae) Scorpion
dc.typeArticle

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