pH responsive itaconic acid grafted alginate microspheres for the controlled release of nifedipine

Basit Öğe Kaydı
dc.contributor.authorIsiklan, Nuran
dc.contributor.authorInal, Murat
dc.contributor.authorKursun, Fatma
dc.contributor.authorErcan, Gulden
dc.date.accessioned2020-06-25T17:51:56Z
dc.date.available2020-06-25T17:51:56Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.description.abstractA series of pH responsive alginate-g-poly(itaconic acid) (NaAlg-g-PIA) microspheres were prepared as drug delivery matrices of nifedipine cross-linked by glutaraldehyde (GA) in the hydrochloric acid catalyst. Graft copolymers of sodium alginate with itaconic acid were synthesized using ceric ammonium nitrate. The chemical stability of the nifedipine after encapsulation into microspheres was confirmed by FTIR, DSC and X-RD analysis. The preparation conditions of the NaAlg-g-PIA microspheres such as graft yield, GA concentration, exposure time to GA and drug amount were optimized by considering the percentage entrapment efficiency, particle size, swelling capacity and their release data. The results showed that NaAlg-g-PIA microspheres are pH responsive. The release of nifedipine from grafted microspheres was slower for the pH 1.2 solution than that of the pH 7.4 buffer solution. It has been observed that an increase in exposure time, drug amount, GA and NaAlg-g-PIA concentrations causes a decrease in the nifedipine release from the microspheres, whereas an increase in graft yield leads to an increase in the nifedipine release. (C) 2010 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [106T492]en_US
dc.description.sponsorshipThe authors are grateful to the TUBITAK for financial support with the project number of 106T492.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.carbpol.2010.12.054
dc.identifier.endpage943en_US
dc.identifier.issn0144-8617
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-79951682126
dc.identifier.scopusqualityQ1
dc.identifier.startpage933en_US
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2010.12.054
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5033
dc.identifier.volume84en_US
dc.identifier.wosWOS:000288231100012
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofCarbohydrate Polymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGraft copolymerizationen_US
dc.subjectSodium alginateen_US
dc.subjectItaconic aciden_US
dc.subjectFree radical copolymerizationen_US
dc.subjectMicrospheresen_US
dc.titlepH responsive itaconic acid grafted alginate microspheres for the controlled release of nifedipineen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
pH responsive itaconic acid grafted alginate microspheres for the controlled release of nifedipine.pdf
Boyut:
973.38 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu