Poly(hexamethylene biguanide) immobilized non-absorbable and antimicrobial PET fiber for surgical suture applications: synthesis, characterization and in vitro cytocompatibility assessment
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Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Surgical sutures are medical devices commonly used to close wounds. However, surgical site infections (SSI) are highly likely to occur around the suture after surgery. In this study, we aimed to synthesize a multi-filament polyethylene terephthalate (PET) based non-absorbable antimicrobial suture to prevent possible CAI. PET fiber was grafted with methacrylic acid (MAA-g-PET) to give it a functional group. MAA-g-PET fibers were immobilized with poly(hexamethylene) biguanide (PHMB), a cationic antiseptic with broad spectrum antibacterial and antifungal activity (PHMB/MAA-g-PET). The synthesis of PHMB/MAA-g-PET fibers was confirmed by SEM, FTIR, DSC and TGA characterizations. The antimicrobial activity of PHMB/MAA-g-PET fiber was investigated against S. aureus and E. coli species and proved to be >99% effective against both species. MTT cytotoxicity assay revealed that PHMB/MAA-g-PET fiber was cytocompatible for L929 fibroblast cells. In addition, in vitro degradation studies showed that the degradation profile of PHMB/MAA-g-PET was not much different from the original PET and retained its non-absorbable property.
Açıklama
Anahtar Kelimeler
Mühendislik, Biyotıp, Biyoteknoloji ve Uygulamalı Mikrobiyoloji, Malzeme Bilimleri, Biyomalzemeler, Cerrahi
Kaynak
Uluslararası Mühendislik Araştırma ve Geliştirme Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
16
Sayı
2
