Poly(hexamethylene biguanide) immobilized non-absorbable and antimicrobial PET fiber for surgical suture applications: synthesis, characterization and in vitro cytocompatibility assessment

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dc.contributor.authorBozkaya, Ogün
dc.contributor.authorGünay, Kübra
dc.contributor.authorBozkaya, Esra
dc.contributor.authorArslan, Metin
dc.date.accessioned2025-01-21T16:13:42Z
dc.date.available2025-01-21T16:13:42Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractSurgical sutures are medical devices commonly used to close wounds. However, surgical site infections (SSI) are highly likely to occur around the suture after surgery. In this study, we aimed to synthesize a multi-filament polyethylene terephthalate (PET) based non-absorbable antimicrobial suture to prevent possible CAI. PET fiber was grafted with methacrylic acid (MAA-g-PET) to give it a functional group. MAA-g-PET fibers were immobilized with poly(hexamethylene) biguanide (PHMB), a cationic antiseptic with broad spectrum antibacterial and antifungal activity (PHMB/MAA-g-PET). The synthesis of PHMB/MAA-g-PET fibers was confirmed by SEM, FTIR, DSC and TGA characterizations. The antimicrobial activity of PHMB/MAA-g-PET fiber was investigated against S. aureus and E. coli species and proved to be >99% effective against both species. MTT cytotoxicity assay revealed that PHMB/MAA-g-PET fiber was cytocompatible for L929 fibroblast cells. In addition, in vitro degradation studies showed that the degradation profile of PHMB/MAA-g-PET was not much different from the original PET and retained its non-absorbable property.
dc.identifier.doi10.29137/umagd.1473795
dc.identifier.endpage790
dc.identifier.issn1308-5514
dc.identifier.issue2
dc.identifier.startpage777
dc.identifier.trdizinid1248864
dc.identifier.urihttps://doi.org/10.29137/umagd.1473795
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1248864
dc.identifier.urihttps://hdl.handle.net/20.500.12587/21984
dc.identifier.volume16
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofUluslararası Mühendislik Araştırma ve Geliştirme Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectMühendislik
dc.subjectBiyotıp
dc.subjectBiyoteknoloji ve Uygulamalı Mikrobiyoloji
dc.subjectMalzeme Bilimleri
dc.subjectBiyomalzemeler
dc.subjectCerrahi
dc.titlePoly(hexamethylene biguanide) immobilized non-absorbable and antimicrobial PET fiber for surgical suture applications: synthesis, characterization and in vitro cytocompatibility assessment
dc.typeArticle

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