Multi-stimuli-sensitive superparamagnetic ?-carrageenan based nanoparticles for controlled 5-fluorouracil delivery
[ X ]
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Herein, a novel multi-stimuli-sensitive nanoparticles with triple magnetic field, temperature, and pH-sensitive features was designed and developed as a drug nanocarrier for delivery of 5-fluorouracil (FL). For this purpose, dimethylaminoethyl methacrylate (DMA) was firstly grafted onto kappa-carrageenan (kappa-CG), and then kappa-CG-gPDMA copolymer was coated onto Fe3O4 nanoparticles via microwave-supported coprecipitation method. The prepared multi-functional magnetic nanoparticles were characterized by UV, FTIR, XRD, TEM, Zeta-sizer, and VSM analyses to confirm the formation of superparamagnetic Fe3O4@kappa-CG-g-PDMA structure. The in vitro FL release of the nanoparticles was investigated at 48 and 37 degrees C in different pH conditions and exhibited good pH- and temperature-sensitive behavior. Furthermore, the effects of graft yield and magnetic field on FL release were explored. When the magnetic field was applied at 100 kHz, the release of FL increased rapidly, demonstrating that nanoparticles had magnetic field-sensitive features. According to the results, the designed Fe3O4@kappa-CG-g-PDMA@FL nanoparticles can be considered as a smart drug delivery system for cancer therapy due to its high entrapment efficiency, slow and multi-stimuli-triggered FL release performance, and satisfactory magnetic properties.
Açıklama
Anahtar Kelimeler
kappa-carrageenan; Iron oxide; Dimethylaminoethyl methacrylate; Multi-stimuli-sensitive nanoparticles
Kaynak
Colloids and Surfaces A-Physicochemical and Engineering Aspects
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
634
