Comparison of clinical characteristics of patients with heart failure and preserved ejection fraction with atrial fibrillation versus sinus rhythm: Insights from the APOLLON registry

Basit Öğe Kaydı
dc.authoridmert, kadir ugur/0000-0002-1331-5365
dc.contributor.authorOzlek, Bulent
dc.contributor.authorOzlek, Eda
dc.contributor.authorTekinalp, Mehmet
dc.contributor.authorKahraman, Serkan
dc.contributor.authorAgus, Hicaz Zencirkiran
dc.contributor.authorBasaran, Ozcan
dc.contributor.authorKaya, Bedri Caner
dc.date.accessioned2025-01-21T16:36:46Z
dc.date.available2025-01-21T16:36:46Z
dc.date.issued2020
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: The aim of this study was to assess the clinical characteristics of patients with heart failure and preserved ejection fraction (HFpEF) and atrial fibrillation (AF) and compare them with those of HFpEF patients without AF. Methods: This study was a sub-group analysis of a multicenter, observational, and cross-sectional registry conducted in Turkey (ClinicalTrials.gov identifier: NCT03026114). Patients with HFpEF were divided into 2 groups: HFpEF with AF and HFpEF with sinus rhythm (SR), and the clinical characteristics of the groups were compared. Results: In a total of 819 HFpEF patients (median age: 67 years; 58% women), 313 (38.2%) had AF. Compared to the patients with SR, those with AF were older (70 years vs 66 years; p<0.001) and more symptomatic, with a higher rate of classification as New York Heart Association functional class III IV, paroxysmal nocturnal dyspnea, orthopnea, palpitations, fatigue, pulmonary crepitations, and peripheral edema. The hospitalization rate for heart failure was higher (28.4% vs 12.6%; p<0.001) in patients with AF, and participants with AF had higher level of N-terminal pro-B-type natriuretic peptide (887 pg/mL vs 394.8 pg/mL; p<0.001) and higher left atrial volume index level. Patients without AF had a higher burden of diabetes mellitus, obstructive sleep apnea, and coronary artery disease. The prescription rate of nondihydropyridine calcium blockers, digoxin, loop diuretics, and anticoagulant drugs was higher in the AF group. Conclusion: The results of this study revealed that in a large Turkish cohort with HFpEF, significant clinical differences were present between those with and without AF and. Further prospective studies are needed to clarify the prognostic implications of AF in this growing heart failure population in our country.
dc.identifier.doi10.5543/tkda.2019.77236
dc.identifier.endpage245
dc.identifier.issn1016-5169
dc.identifier.issue3
dc.identifier.pmid32281959
dc.identifier.startpage234
dc.identifier.urihttps://doi.org/10.5543/tkda.2019.77236
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24382
dc.identifier.volume48
dc.identifier.wosWOS:000526091700003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives of The Turkish Society of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAtrial fibrillation; clinical differences; heart failure with preserved ejection fraction; sinus rhythm; Turkey
dc.titleComparison of clinical characteristics of patients with heart failure and preserved ejection fraction with atrial fibrillation versus sinus rhythm: Insights from the APOLLON registry
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu