Is There a Relationship between Optic Nerve and Chiasm Measurements with HbA1c Levels in Diabetic Patients?

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dc.authoridBekin Sarikaya, Pelin Zeynep/0000-0001-9588-6702
dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.contributor.authorSarikaya, Pelin Zeynep Bekin
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorOzdemirl, Adnan
dc.contributor.authorGungunes, Askin
dc.date.accessioned2025-01-21T16:42:15Z
dc.date.available2025-01-21T16:42:15Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives We investigated the optic nerve (ON) and chiasm (OC) in magnetic resonance (MR) in diabetic patients by comparing them with hemoglobin A1c (HbA1c) levels.Methods In this retrospective study, cranial MRIs of 42 adults (19 males and 23 females) with diabetes mellitus (DM) (group1) and 40 healthy controls (19 males and 21 females) (group 2) were included. In both groups, bilateral ON widths and OC area, width, and height were measured. In the DM group, HbA1c values were also obtained at the time of MRI or within the same month.Results In the DM group, the mean of the HbA1c values was 8.31 & PLUSMN; 2.51%. There were no significant differences between ON diameter; and OC area, width and height of the DM and control groups ( p > 0.05). In each of the DM and control groups, ON diameter was not different between the right and left sides ( p > 0.05). In DM groups, correlation tests showed that there were positive correlations between right and left ON diameters, OC area and OC width, and OC height ( p < 0.05). In males, ON diameters were higher than those in females bilaterally ( p < 0.05). In patients with higher HbA1c values, OC width was smaller ( p < 0.05).Conclusion A significant correlation of OC width and HbA1c levels suggests that uncontrolled DM causes ON atrophy. Our study represents a thorough assessment of OC measures using standard brain MRI to evaluate optic degeneration in DM patients and shows that the OC width measurement is suitable and reliable. This simple method can be obtained from clinically available scans.
dc.identifier.doi10.1055/s-0042-1758146
dc.identifier.endpage199
dc.identifier.issn2193-6331
dc.identifier.issn2193-634X
dc.identifier.issue2
dc.identifier.pmid36895815
dc.identifier.startpage194
dc.identifier.urihttps://doi.org/10.1055/s-0042-1758146
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25031
dc.identifier.volume84
dc.identifier.wosWOS:000884347500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherThieme Medical Publ Inc
dc.relation.ispartofJournal of Neurological Surgery Part B-Skull Base
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectdiabetes mellitus; HbA1c; optic nerve; optic chiasm; atrophy; cranial MRI
dc.titleIs There a Relationship between Optic Nerve and Chiasm Measurements with HbA1c Levels in Diabetic Patients?
dc.typeArticle

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