Hekzaklorosiklotrifosfazen ile Yeni Bir N-İkame Edilmiş Aminoalkol Türevinin Tasarımı ve Sentezi
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Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kırıkkale Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Hekzaklorosiklotrifosfazen, N3P3Cl6, aminler, alkoller, vb., nükleofiller ile sübstitüsyon reaksiyonları veren halkalı bileşiklerdir. Siklotrifosfazenin dioller, diaminler ve aminoalkoller gibi bifonksiyonel nükleofillerle nükleofilik sübstitüsyon reaksiyonları on yıllardır yoğun bir çalışma konusu olmuştur. Fosfazenlerdeki kararlı P=N bağı nedeniyle, fosfazen türevleri ısıya, radyasyona, yanmaya, indirgeyici ve oksitleyici maddelere karşı direnç gibi özelliklere sahip olabilir. Siklofosfazen türevleri genellikle biyolojik uyumluluğa sahiptir ve toksik olmayan küçük moleküllere ayrışır, bu nedenle biyolojik aktiviteler ve DNA etkileşimleri için avantajlıdır. Bu nedenle siklik fosfazen bileşiklerinin özellikleri, antikanserojen, antibakteriyel ve DNA etkileşimleri halen üzerinde çalışılan konulardır.N/O donör tip bifonksiyonel N-sübstitüe aminoalkollerin hekzaklorosiklotrifosfazen ile kondenzasyon reaksiyonları incelendi ve spiro-siklik tetraklorosiklotrifosfazen türevleri (1 - 4) hazırlandı. Tüm bileşikleri karakterize etmek için element analizleri, ESI-MS, FT-Raman, FTIR ve NMR spektroskopi teknikleri kullanıldı.
Hexachlorocyclotriphosphazene, N3P3Cl6, are cyclical and give substitution reactions with amines, alcohols, etc., nucleophiles. Nucleophilic substitution reactions of cyclotriphosphazene with bifunctional nucleophiles such as diols, diamines and aminoalcohols have been a subject of intense study over decades. Due to the stable P=N bond in phosphazenes, phosphazene derivatives can have properties such as resistance to heat, radiation, combustion, reducing and oxidizing substances. Cyclophosphazene derivatives usually have biological compatibility and degrade into non-toxic small molecules, thus are advantageous to biological activities and DNA interactions. For this reason, the properties of cyclic phosphazene compounds, anticarcinogenic, antibacterial and DNA interactions are currently studied topics. The condensation reactions of N/O donor type bifunctional N-substituted aminoalcohols with hexachlorocyclotriphosphazene were investigated and the spiro-cyclic tetrachlorocyclotriphosphazene derivatives (1 - 4) were prepared. Elemental analyses, ESI-MS, FT-Raman, FTIR and NMR spectroscopy techniques were employed to characterize all of the compounds.
Hexachlorocyclotriphosphazene, N3P3Cl6, are cyclical and give substitution reactions with amines, alcohols, etc., nucleophiles. Nucleophilic substitution reactions of cyclotriphosphazene with bifunctional nucleophiles such as diols, diamines and aminoalcohols have been a subject of intense study over decades. Due to the stable P=N bond in phosphazenes, phosphazene derivatives can have properties such as resistance to heat, radiation, combustion, reducing and oxidizing substances. Cyclophosphazene derivatives usually have biological compatibility and degrade into non-toxic small molecules, thus are advantageous to biological activities and DNA interactions. For this reason, the properties of cyclic phosphazene compounds, anticarcinogenic, antibacterial and DNA interactions are currently studied topics. The condensation reactions of N/O donor type bifunctional N-substituted aminoalcohols with hexachlorocyclotriphosphazene were investigated and the spiro-cyclic tetrachlorocyclotriphosphazene derivatives (1 - 4) were prepared. Elemental analyses, ESI-MS, FT-Raman, FTIR and NMR spectroscopy techniques were employed to characterize all of the compounds.
Açıklama
Anahtar Kelimeler
Siklofosfazenler, Spiro-fosfazenler, N-substite aminoalkoller., Cyclophosphazenes, Spiro-phosphazenes, N-substituted aminoalcohols.”, Bioengineering (Other)
Kaynak
Uluslararası Mühendislik Araştırma ve Geliştirme Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
1
Sayı
3-74
