Aptamer-functionalized magnetic graphene oxide nanocarrier for targeted drug delivery of paclitaxel

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dc.contributor.authorHussien, Nizamudin Awel
dc.contributor.authorIsiklan, Nuran
dc.contributor.authorTurk, Mustafa
dc.date.accessioned2020-06-25T18:29:37Z
dc.date.available2020-06-25T18:29:37Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.description.abstractTargeted drug delivery has come out as a golden system owing to its capability to reduce side effects and increase efficacy. The application of graphene oxide (GO) based nanomaterials for targeted delivery has recently attracted several researchers because of their advantageous properties. Herein, we have attempted to prepare aptamer-conjugated magnetic graphene oxide (MGO) nanocarrier, which can specifically target tumor cells. MGO nanocarriers were prepared by attaching Fe3O4 on the layer of GO and then, aptamer (APT) was linked as a targeting moiety. Paclitaxel (PAC), an anti-cancer drug, was also loaded on the nanocarrier. PAC loading and in vitro release results revealed a very good loading performance with entrapment efficiency 95.75% and high pH-responsive release. Cellular toxicity assay showed MGO nanocarriers are biocompatible having cell viability greater than 80% for L-929 fibroblast cell line. Besides, high cytotoxic effect was observed for PAC and PAC loaded MGO (MGO@PAC) on MCF-7 cancer cells, at different drug doses. Furthermore, flow cytometry investigation reveals that the obtained nanocarrier can specifically bind to MCF-7 cancer cells. Therefore, based on the results the prepared superparamagnetic nanocarrier could be considered as a promising agent for cancer drug delivery systems. (C) 2018 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipKinkkale University [2017/020]en_US
dc.description.sponsorshipThe authors are grateful for financial support from Kinkkale University under project number 2017/020, 2017. We are also thankful to Assoc. Prof. Dr. Eyup Duman, Ankara University, Department of Energy Engineering for carrying out VSM analysis.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.matchemphys.2018.03.015
dc.identifier.endpage488en_US
dc.identifier.issn0254-0584
dc.identifier.issn1879-3312
dc.identifier.scopus2-s2.0-85046018521
dc.identifier.scopusqualityQ1
dc.identifier.startpage479en_US
dc.identifier.urihttps://doi.org/10.1016/j.matchemphys.2018.03.015
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7395
dc.identifier.volume211en_US
dc.identifier.wosWOS:000430774300059
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Saen_US
dc.relation.ispartofMaterials Chemistry And Physics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMagnetic graphene oxideen_US
dc.subjectNanocarrieren_US
dc.subjectTargeted drug deliveryen_US
dc.subjectBiocompatibilityen_US
dc.titleAptamer-functionalized magnetic graphene oxide nanocarrier for targeted drug delivery of paclitaxelen_US
dc.typeArticle

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