The effect of circulating nitric oxide level on axial bone mineral density in postmenopausal Turkish women with rheumatoid arthritis: A preliminary report

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dc.contributor.authorŞahin, Günşah
dc.contributor.authorGüler, Hayal
dc.contributor.authorSezgin, Melek
dc.contributor.authorİncel, Nurgül A.
dc.contributor.authorPolat, Gürbüz
dc.date.accessioned2020-06-25T15:13:41Z
dc.date.available2020-06-25T15:13:41Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe aim is to investigate the differences in the circulating nitric oxide (NO) levels of rheumatoid arthritis (RA) patients, healthy controls and osteoporotic (OP) patients. We also examined whether the circulating NO levels may be correlated with bone mineral density (BMD) in RA patients. Forty-five patients with RA, 30 healthy women and 30 osteoporotic patients were recruited from the outpatient clinic. All the subjects were female and postmenopausal. Serum NO levels were measured (Nitrite/Nitrate, calorimetric method 1746081, Roche diagnostics, Mannheim, Germany) and BMD was measured at the spine and hip using dual energy X-Ray absorbtiometry (DEXA, Norland XR-46). Height and weight were measured and body mass index was calculated. Circulating NO levels were significantly higher in RA patients than other groups. Moreover, the RA group showed significantly higher BMD at lumbar spine and femoral neck regions compared to osteoporotic patients. However, the RA group showed significantly lower BMD at all sites than the controls. There was no correlation between circulating NO levels and BMD in all groups. We suggest that, unlike postmenopausal osteoporosis, inflammation induced osteoporosis is associated with RA is characterised by relatively preserved bone mass at the axial bone regions, and circulating NO levels as a parameter or determinant of inflammation are not correlated with axial BMD in RA patients. © Springer-Verlag 2005.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00296-005-0091-2
dc.identifier.endpage809en_US
dc.identifier.issn01728172
dc.identifier.issue9en_US
dc.identifier.pmid16362366
dc.identifier.scopus2-s2.0-33745064872
dc.identifier.scopusqualityQ1
dc.identifier.startpage805en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-005-0091-2
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1896
dc.identifier.volume26en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofRheumatology International
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone mineral densityen_US
dc.subjectNitric oxideen_US
dc.subjectRheumatoid arthritisen_US
dc.titleThe effect of circulating nitric oxide level on axial bone mineral density in postmenopausal Turkish women with rheumatoid arthritis: A preliminary reporten_US
dc.typeArticle

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