Evaluation of Oxidative Stress Biomarkers in Patients with Henoch-Schönlein Purpura

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dc.contributor.authorSoylemez, Kadir
dc.contributor.authorTemiz, Fatih
dc.contributor.authorDalkiran, Tahir
dc.contributor.authorKandur, Yasar
dc.contributor.authorBelge Kurutas, Ergul
dc.contributor.authorUnsal, Velid
dc.contributor.authorOner, Erkan
dc.date.accessioned2025-01-21T16:27:34Z
dc.date.available2025-01-21T16:27:34Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractINTRODUCTION: Henoch-Schönlein Purpura (HSP) is a systemic vasculitic syndrome characterized by non-thrombocytopenic purpura, arthritis/arthralgia, abdominal pain, and glomerulonephritis. The pathogenesis of HSP has not been clearly identified. Oxidative damage has a role in the pathogenesis of most cases. AIM: This study aimed to evaluate changes of oxidative stress by studying parameters like superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) in an attempt to identify the role of oxidative stress in HSP from another perspective. MATERIALS AND METHODS: This study enrolled 23 pediatric patients (ten girls and thirteen boys) diagnosed with HSP who were under follow-up at Sutcu Imam University School of Medicine Department of Pediatrics between 2014 and 2016 and twenty healthy children as the control group. The parents of all subjects gave informed consent to participate in the study. In the HSP group, the beginning season of the illness and the systemic involvement during follow-up were determined. Blood specimens were obtained at presentation before any treatment was started. SOD, CAT activities, and MDA values in erythrocyte and plasma samples were compared between the patient group and the healthy children. RESULTS: Twenty-three patients with HSP (13 males, 10 females) and 20 healthy children participated in this study. The mean age of the HSP cases was 8.21±3.78 years (range 2-16 years) and of the controls was 8.6±4.2 (range 3-14 years). The mean MDA value was 2.95±0.71 nmol/ml in the patient group and 2.67±0.66 nmol/ml in the control group (p=0.787). The mean level of the CAT enzyme was 1.32±0.35 U/g Hb in the patient group and 7.8±1.74 U/g Hb in the control group (p=0.001). The mean levels of the SOD enzyme were 3.06±0.85 U/g Hb in the patient group and 0.97±0.36 U/g Hb in the control group (p=0.001). CONCLUSIONS: Although high MDA levels support the role of lipid peroxidation in the pathogenesis of HSP, statistical significance was not reached owing to a limited number of our patients. The reduced CAT enzyme activity is consistent with the findings of previous reports. This finding supports the notion that oxidative stress can play a role in the pathogenesis of HSP. KEYPOINTS: Our findings support the notion that oxidative stress can play a role in the pathogenesis of HSP. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.identifier.doi10.3897/folmed.63.e59406
dc.identifier.endpage931
dc.identifier.issn1314-2143
dc.identifier.issue6
dc.identifier.pmid35851226
dc.identifier.scopus2-s2.0-85134554051
dc.identifier.scopusqualityQ3
dc.identifier.startpage928
dc.identifier.urihttps://doi.org/10.3897/folmed.63.e59406
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23364
dc.identifier.volume63
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofFolia medica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectHenoch-Schönlein purpura; oxidative stress; pediatric
dc.titleEvaluation of Oxidative Stress Biomarkers in Patients with Henoch-Schönlein Purpura
dc.typeArticle

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