Evaluation Of Oxidative Stress On Dogs With Demodicosis
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Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To investigate the effects of oxidative stress in dogs with demodicosis. Materials and Methods: The material of the study was based on a total of 32 owned dogs, of which 21 were diagnosed with demodicosis and 11 were healthy, with different ages, genders, and breeds. Demodex examination for diagnostic evaluation was performed by examining samples under the microscope that were taken using the trichogram and deep skin scraping methods. In order to evaluate the effects of oxidative stress in dogs with demodicosis in the pre- and post-treatment groups and the control group without demodex diagnosis, the superoxide dismutase (SOD), glutathione peroxidase (GPX), and glutathione (GSH) values, as antioxidants and malondialdehyde (MDA) as an oxidant, were investigated. Results: In the clinical examinations, manifestations such as alopecia, erythema, generalized pruritus, hyperpigmentation, lichenification, pododermatitis, interdigital pruritus, and lymphadenopathy were observed in the dogs with demodicosis both pre- and post-treatment. In the analyses performed in order to evaluate the oxidative stress, MDA: 20.30 nmol/mL, GSH: 4.9 nmol/mL, GPx: 0.42 U/L, and SOD: 4.1 U/L were measured in the dogs with clinical demodicosis. Post-treatment, the average values in the same dogs were measured as MDA: 6.08 nmol/mL, GSH: 8.11 nmol/mL, GPx: 0.83 U/L, and SOD: 6.67 U/L, while in the control group, they were measured as MDA: 4.94 nmol/mL, GSH: 9.73 nmol/mL, GPx: 0.97 U/L, and SOD: 7.20 U/L. It was determined that the GSH, GPx, and SOD values in the control and post-treatment groups were significantly higher (P ? 0.001) and the MDA values were lower (P ? 0.001) than in the clinical demodicosis group. Conclusion: In dogs with clinical demodicosis, when compared to the control and post-treatment groups, higher levels of MDA, which is an oxidant, and lower levels of GSA, GPx, and SOD, which are antioxidants, showed that demodex caused oxidative stress in the dogs..
Açıklama
Anahtar Kelimeler
Biyoloji, Veterinerlik
Kaynak
Turkish Journal of Veterinary Research (Online)
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
1
