Evaluation Of Oxidative Stress On Dogs With Demodicosis

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dc.contributor.authorSivel, Gozde Nur
dc.contributor.authorYağcı, Buğrahan Bekir
dc.date.accessioned2025-01-21T16:11:20Z
dc.date.available2025-01-21T16:11:20Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: To investigate the effects of oxidative stress in dogs with demodicosis. Materials and Methods: The material of the study was based on a total of 32 owned dogs, of which 21 were diagnosed with demodicosis and 11 were healthy, with different ages, genders, and breeds. Demodex examination for diagnostic evaluation was performed by examining samples under the microscope that were taken using the trichogram and deep skin scraping methods. In order to evaluate the effects of oxidative stress in dogs with demodicosis in the pre- and post-treatment groups and the control group without demodex diagnosis, the superoxide dismutase (SOD), glutathione peroxidase (GPX), and glutathione (GSH) values, as antioxidants and malondialdehyde (MDA) as an oxidant, were investigated. Results: In the clinical examinations, manifestations such as alopecia, erythema, generalized pruritus, hyperpigmentation, lichenification, pododermatitis, interdigital pruritus, and lymphadenopathy were observed in the dogs with demodicosis both pre- and post-treatment. In the analyses performed in order to evaluate the oxidative stress, MDA: 20.30 nmol/mL, GSH: 4.9 nmol/mL, GPx: 0.42 U/L, and SOD: 4.1 U/L were measured in the dogs with clinical demodicosis. Post-treatment, the average values in the same dogs were measured as MDA: 6.08 nmol/mL, GSH: 8.11 nmol/mL, GPx: 0.83 U/L, and SOD: 6.67 U/L, while in the control group, they were measured as MDA: 4.94 nmol/mL, GSH: 9.73 nmol/mL, GPx: 0.97 U/L, and SOD: 7.20 U/L. It was determined that the GSH, GPx, and SOD values in the control and post-treatment groups were significantly higher (P ? 0.001) and the MDA values were lower (P ? 0.001) than in the clinical demodicosis group. Conclusion: In dogs with clinical demodicosis, when compared to the control and post-treatment groups, higher levels of MDA, which is an oxidant, and lower levels of GSA, GPx, and SOD, which are antioxidants, showed that demodex caused oxidative stress in the dogs..
dc.identifier.doi10.47748/tjvr.1119988
dc.identifier.endpage13
dc.identifier.issn2602-3695
dc.identifier.issue1
dc.identifier.startpage7
dc.identifier.trdizinid1164728
dc.identifier.urihttps://doi.org/10.47748/tjvr.1119988
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1164728
dc.identifier.urihttps://hdl.handle.net/20.500.12587/21464
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Veterinary Research (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectBiyoloji
dc.subjectVeterinerlik
dc.titleEvaluation Of Oxidative Stress On Dogs With Demodicosis
dc.typeArticle

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