Using nanogap in label-free impedance based electrical biosensors to overcome electrical double layer effect

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dc.contributor.authorOkyay, Ali Kemal
dc.contributor.authorHanoglu, Oguz
dc.contributor.authorYuksel, Mustafa
dc.contributor.authorAcar, Handan
dc.contributor.authorSulek, Selim
dc.contributor.authorTekcan, Burak
dc.contributor.authorGuler, Mustafa O.
dc.date.accessioned2020-06-25T18:23:06Z
dc.date.available2020-06-25T18:23:06Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionGuler, Mustafa/0000-0003-1168-202X; Acar, Handan/0000-0001-8708-9279
dc.description.abstractPoint-of-care biosensor applications require low-cost and low-power solutions. They offer being easily accessible at home site. They are usable without any complex sample handling or any kind of special expertise. Impedance spectroscopy has been utilized for point-of-care biosensor applications; however, electrical double layer formed due to ions in the solution of interest has been a challenge, due to shielding of the electric field used for sensing the target molecules. Here in this study, we demonstrate a nanogap based biosensor structure with a relatively low frequency (1-100 kHz) measurement technique, which not only eliminates the undesired shielding effect of electrical double layer but also helps in minimizing the measurement volume and enabling low concentration (A mu molar level) detection of target molecules (streptavidin). Repeatability and sensitivity tests proved stable and reliable operation of the sensors. These biosensors might offer attributes such as low-cost label-free detection, fast measurement and monolithic chip integrability.en_US
dc.description.sponsorshipEuropean Union Framework Program 7 Marie Curie IRG [239444, 249196]; COST NanoTPEuropean Cooperation in Science and Technology (COST); TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109E044, 112M004, 112E052, 112M944, 113M815]; TUBITAK-BIDEBTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipThis work was supported in part by European Union Framework Program 7 Marie Curie IRG Grant 239444 and 249196, COST NanoTP, TUBITAK Grants 109E044, 112M004, 112E052, 112M944 and 113M815. The authors acknowledge support from TUBITAK-BIDEB. The authors thank Firat Yilmaz for his contributions and Dr. Mohammad Ghaffari for SEM images.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00542-015-2764-4
dc.identifier.endpage897en_US
dc.identifier.issn0946-7076
dc.identifier.issn1432-1858
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84951983992
dc.identifier.scopusqualityQ2
dc.identifier.startpage889en_US
dc.identifier.urihttps://doi.org/10.1007/s00542-015-2764-4
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7011
dc.identifier.volume23en_US
dc.identifier.wosWOS:000397499300008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofMicrosystem Technologies-Micro-And Nanosystems-Information Storage And Processing Systems
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleUsing nanogap in label-free impedance based electrical biosensors to overcome electrical double layer effecten_US
dc.typeArticle

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