Rabbit Retinal Ganglion Cell Activation Thresholds in Response to Various Electrical Stimulation Waveforms using a Different Spatial Resolution Electrode Array

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dc.contributor.authorCelik, M. E.
dc.contributor.authorOzden, M.
dc.contributor.authorKaragoz, I.
dc.contributor.authorSobaci, G.
dc.date.accessioned2020-06-25T18:22:57Z
dc.date.available2020-06-25T18:22:57Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionSobaci, Gungor/0000-0002-3533-0224
dc.description.abstractThe analysis of retinal ganglion cell responses to electrical stimulation is invaluable way to understand how the retina reacts and develops. Artificial visual prosthetics have made progress to some extent. Although there are several studies about retinal ganglion cell responses in the literature, experimental findings and information about responses to special stimulation patterns for developing high-resolution visual prosthetics are quite limited. In this study, rabbit retinal tissue was stimulated by biphasic, monophasic and ramp function current pulses with various amplitudes and pulse widths in a set of in vitro experiments. Rabbit retinal ganglion cell responses and spike activities are comparatively analyzed based on the applied electrical stimulation parameters. We conclude that biphasic current pulses provide a lower stimulation threshold of 10 mu A with shorter pulse widths than those obtained by monophasic stimulation. Additionally, despite the fact that ramp function stimulation patterns have remarkable potential for eliciting spike formation with low stimulation thresholds, biphasic stimulation is charge-balanced and more convenient for high-resolution visual prosthesis systems.en_US
dc.description.sponsorshipTurkish Scientific and Technological Research Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113E181]en_US
dc.description.sponsorshipThis work is supported by Turkish Scientific and Technological Research Council (TUBITAK), Project Code: 113E181. Ethical statement: the Gulhane Military Medical Academy (GMMA) Animal Experiments Ethics Board approved the care and use of animals. It means that animal investigations are conducted according to the principles expressed in the Declaration of Helsinki.en_US
dc.identifier.citationCelik, Mahmut & Özden, Merve & Karagöz, İ & Sobaci, G.. (2017). Rabbit Retinal Ganglion Cell Activation Thresholds in Response to Various Electrical Stimulation Waveforms using a Different Spatial Resolution Electrode Array. Acta Physica Polonica A. 131. 1479-1484.en_US
dc.identifier.doi10.12693/APhysPolA.131.1479
dc.identifier.endpage1484en_US
dc.identifier.issn0587-4246
dc.identifier.issn1898-794X
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85023187548
dc.identifier.scopusqualityQ3
dc.identifier.startpage1479en_US
dc.identifier.urihttps://doi.org/10.12693/APhysPolA.131.1479
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6964
dc.identifier.volume131en_US
dc.identifier.wosWOS:000405380300012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPolish Acad Sciences Inst Physicsen_US
dc.relation.ispartofActa Physica Polonica A
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleRabbit Retinal Ganglion Cell Activation Thresholds in Response to Various Electrical Stimulation Waveforms using a Different Spatial Resolution Electrode Arrayen_US
dc.typeArticle

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