Crevicular fluid levels of interleukin-8, interleukin-17 and soluble intercellular adhesion molecule-1 after regenerative periodontal therapy
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Date
2015
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Dental Investigations Society
Access Rights
info:eu-repo/semantics/openAccess
Abstract
Objective: The aim of this study is to evaluate the influence of regenerative periodontal therapy on clinical parameters and interleukin-8 (IL-8), IL-17 and soluble intercellular adhesion molecule-1 (sICAM-1) levels in gingival crevicular fluid (GCF) of subjects with chronic periodontitis (CP). Materials and Methods: Fifteen patients received demineralized freeze-dried bone allograft (DFDBA) surgically to the site of infrabony defect. Clinical periodontal indices were recorded, and GCF samples were collected at baseline and at the 6th and the 9th month after the surgery. Results: Except plaque index, all clinical parameters improved following surgery (P < 0.05). The volume of GCF diminished from baseline to follow-up periods (P < 0.05). However, no effect was observed on the total amount of IL-8, IL-17 and sICAM-1 in GCF. Conclusion: DFDBA improved clinical outcome in CP subjects and was effective on decreasing the volume of GCF, but no effect was determined on IL-8, IL-17 and sICAM-1. Findings did not indicate a direct relationship between biochemical parameters and periodontal healing after demineralized freeze-dried bone grafting. © 2015 Dental Investigations Society.
Description
Keywords
Demineralized freeze-dried bone allograft, Gingival crevicular fluid, Interleukin-17, Interleukin-8, Soluble intercellular adhesion molecule-1
Journal or Series
European Journal of Dentistry
WoS Q Value
Scopus Q Value
Q1
Volume
9
Issue
1
