Light and electron microscopic studies on liver histology in chicks fed aflatoxin

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dc.contributor.authorErgün E.
dc.contributor.authorErgün L.
dc.contributor.authorEşsiz D.
dc.date.accessioned2020-06-25T15:13:38Z
dc.date.available2020-06-25T15:13:38Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThis study was carried out under both light and electron microscopy to investigate the effects on liver carbohydrate and lipid metabolism caused by aflatoxin (AF) fed to chicks. Twenty broiler chicks were used. The birds were housed in electrically heated battery cages and exposed to light for 24 h. Feed and water were provided ad libitum. The animals were allocated to two groups each made up of 10 broilers. Total aflatoxin levels of zero (0) and 5 mg of AF/kg feed (81.05 % AFB1, 8.79 % AFG1, 6.06 % AFB 2, and 4.10 % AFG2) added to a commercial diet, were fed to chicks from hatching up to 3 weeks of age, when the experiment was terminated. The chicks were executed by cervical dislocation and liver samples were obtained for light and electron microscopy. Oil red 'O', Sudan Black B, periodic acid Schiff (PAS) and Best's carmine stains were used to reveal fat and glycogen in the liver. Histological changes in hepatocytes included increased lipid droplets, high glycogen content, and mild mononuclear cell infiltration in the portal areas. Ultrastructural findings were destruction of rough endoplasmic reticulum (rER), reduction in mitochondrial size, enlargement of bile canaliculi, and cisternal dilatation of the smooth endoplasmic reticulum (sER).en_US
dc.identifier.endpage368en_US
dc.identifier.issn03416593
dc.identifier.issue10en_US
dc.identifier.pmid17078529
dc.identifier.scopus2-s2.0-33750346854
dc.identifier.scopusqualityN/A
dc.identifier.startpage363en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1880
dc.identifier.volume113en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofDeutsche Tierarztliche Wochenschrift
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAflatoxinen_US
dc.subjectBroiler chicken_US
dc.subjectGlycogenen_US
dc.subjectLipiden_US
dc.subjectLiveren_US
dc.titleLight and electron microscopic studies on liver histology in chicks fed aflatoxinen_US
dc.typeArticle

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