Case with atrophy and proximal muscle weakness: seronegative Lambert Eaton Myasthenic Syndrome

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dc.contributor.authorSay, Bahar
dc.contributor.authorErgün, Ufuk
dc.contributor.authorKaraca, Gülten
dc.date.accessioned2025-01-21T16:27:04Z
dc.date.available2025-01-21T16:27:04Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractLambert Eaton Myasthenic Syndrome (LEMS) is a rare neuromuscular junction disease characterized by proximal muscle weakness, decrease or loss of reflexes, moderate ocular and autonomic findings with antibody development to presynaptic voltage-dependent calcium channels. It can be paraneoplastic or autoimmun. Paraneoplastic LEMS is most commonly associated with small-cell lung cancer. Primary autoimmune may be associated with diabetes, rheumatoid arthritis, systemic lupus erythematosus, autoimmune thyroid diseases. Diagnosis is based clinical findings and electrophsyologic studies include repetetif nerve stimulation or single fiber electromyelography. Treatment includes 3,4 diaminopyridine, intravenous immunglobulin, plasmapheresis, prednisolone and azothiopurine according to the case. © 2019, Pamukkale University. All rights reserved.
dc.identifier.doi10.31362/patd.453646
dc.identifier.endpage183
dc.identifier.issn1309-9833
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85127005920
dc.identifier.scopusqualityQ4
dc.identifier.startpage181
dc.identifier.trdizinid514481
dc.identifier.urihttps://doi.org/10.31362/patd.453646
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/514481
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23249
dc.identifier.volume12
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.publisherPamukkale University
dc.relation.ispartofPamukkale Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectautonomic findings; Lambert Eaton Myasthenic Syndrome; Proximal muscle weakness
dc.titleCase with atrophy and proximal muscle weakness: seronegative Lambert Eaton Myasthenic Syndrome
dc.title.alternativeAtrofi ve proksimal kas güçsüzlüğü olan olgu: seronegatif Lambert Eaton Myastenik Sendrom
dc.typeArticle

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