Predictive value of Tp-e interval, Tp-e/QT, and Tp-e/QTc for disease severity in patients with liver cirrhosis

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dc.contributor.authorBarutcu, S.
dc.contributor.authorInanc, I.
dc.contributor.authorSabanoglu, C.
dc.contributor.authorPolat, E.
dc.date.accessioned2025-01-21T16:43:36Z
dc.date.available2025-01-21T16:43:36Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: The cardiovascular system is one of the most affected systems in the liver cirrhosis (LC) process, especially due to the tendency to arrhythmia. Since the data about the relationship between LC and novel electrocardiography (ECG) indexes are lacking, we aimed to investigate the association between LC and Tp-e interval, Tp-e/QT, and Tp-e/QTc ratio.PATIENTS AND METHODS: The study included 100 patients in the study group (56 male, median age 60) and 100 in the control group (52 female, 60 median age) between January 2021 and January 2022. ECG indexes and laboratory findings were analyzed. RESULTS: The patient group had significant-ly higher heart rate (HR), Tp-e, Tp-e/QT, and Tp-e/ QTc compared to the control group (p < 0.001 for all). There was no difference in terms of QT, QTc, QRS (depolarization of ventricles, involving Q, R, and S waves on ECG) duration, and ejection fraction between the two groups. Kruskal-Wal-lis test results revealed that there was a signifi-cant difference between Child stages in terms of HR, QT, QTc, Tp-e, Tp-e/QT, Tp-e/QTc, and QRS duration. There was also a significant difference between the model for end-stage liver disease (MELD) score groups in terms of all these param-eters except for Tp-e/QTc. In the ROC analyses of Tp-e, Tp-e/QT and Tp-e/QTc to predict the Child C, the AUC values were 0.887; (95% CI: 0.853-0.921), 0.730; (95% CI: 0.680-0.780), and 0.670; (95% CI: 0.614-0.726), respectively. Similarly, AUC values for the MELD score > 20 were 0.877; (95% CI: 0.854-0.900), 0.935; (95% CI: 0.918-0.952), and 0.861; (95% CI: 0.835-0.887); (p < 0.001 for all).CONCLUSIONS: Tp-e, Tp-e/QT, and Tp-e/QTc values were significantly higher in patients with LC. These indexes can be useful for arrhythmia risk stratification and to predict the end-stage of the disease.
dc.description.sponsorship[2022.06.19]
dc.description.sponsorshipEthics Approval The study was approved by the local Ethics Committee of K?r?kkale University (Decision number: 2022.06.19) .
dc.identifier.endpage1120
dc.identifier.issn1128-3602
dc.identifier.issue3
dc.identifier.pmid36808359
dc.identifier.startpage1110
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25300
dc.identifier.volume27
dc.identifier.wosWOS:000943329300011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectLiver cirrhosis; Arrhythmia; Tp-e interval; Tp-e/QT ratio; Tp-e/QTc ratio
dc.titlePredictive value of Tp-e interval, Tp-e/QT, and Tp-e/QTc for disease severity in patients with liver cirrhosis
dc.typeArticle

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