p16INK4a, and p14ARF Expressions in Carcinogenesis of Squamous Cell Carcinoma of the Lip

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dc.contributor.authorAkatli, Ayse Nur
dc.contributor.authorAyva, Ebru Sebnem
dc.contributor.authorBozdogan, Onder
dc.date.accessioned2025-01-21T16:43:18Z
dc.date.available2025-01-21T16:43:18Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe goal of this study was to clarify the role of p16(INK4a), p14(ARF), and p53 protein expressions in carcinogenesis in squamous cell carcinomas of the lip. The expressions of the p53, p16(INK4a), and p14(ARF) proteins were examined in 46 formaline-fixed paraffin embedded tissue specimens, which included 19 cases of squamous cell carcinoma of the lip, 14 cases of actinic cheilitis, and 13 cases of normal mucosa. Immunoreactivity in the peritumoral epithelium adjacent to squamous cell carcinomas was also evaluated. p16(INK4a) expression was increased in actinic cheilitis in comparison with normal mucosa (p=0.001). p14(ARF) expression progressively increased from normal mucosa to actinic cheilitis (p=0.001) and was observed to decrease significantly during the process of transition from actinic cheilitis to carcinoma (p=0.003). p53 values progressively increased from normal mucosa to actinic cheilitis (p=0.001) and carcinoma (p=0.008). A significant positive correlation was found between p14(ARF) and p53 in the peritumoral epithelium adjacent to carcinomas. Our findings indicated that p16(INK4a) and p14(ARF) immunohistochemistry does not determine whether or not actinic cheilitis has the potential to develop carcinoma. The p14(ARF) /p53 pathway is activated in the peritumoral epithelium adjacent to carcinoma; however, this activation would not be adequate to prevent carcinogenesis.
dc.identifier.doi10.51847/vezzdfuPIf
dc.identifier.endpage8
dc.identifier.issn2278-0513
dc.identifier.issue3
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.51847/vezzdfuPIf
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25235
dc.identifier.volume11
dc.identifier.wosWOS:000903665300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherMiddle Eastern Assoc Cancer Research
dc.relation.ispartofClinical Cancer Investigation Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectActinic cheilitis; Carcinogenesis; Lip; p16(INK4a); p14ARF
dc.titlep16INK4a, and p14ARF Expressions in Carcinogenesis of Squamous Cell Carcinoma of the Lip
dc.typeArticle

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