Physicochemical and biological assessment of boron nitride nanosheets-reinforced poly(2-hydroxyethylmethacrylate) composite for biomedical applications
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Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Research on mechanically advanced materials for biological applications involving load-bearing is in progress. Within this scope, this study is the first to propose the fabrication of bionanocomposites combining the different amounts of functionalized boron nitride nanosheets (f-BNNSs, 0-2.0 mg/mL) and poly(hydroxyethyl methac-rylate) (pHEMA). The pristine BN was exfoliated by microwave irradiation to access BNNSs at different powers and times. The as-exfoliated BNNSs were characterized by zeta-sizer, FTIR, XRD, and TEM, which showed that the BNNSs exhibited facile and processable features in tiny sizes. Bionanocomposites were fabricated by pho-topolymerization. The physical, chemical, and mechanical properties, hydrophilic behavior, and degradability of bionanocomposites were evaluated. The mechanical parameters such as Young's modulus and elongation per-centage at break showed that adding f-BNNSs up to 2.0 mg/mL significantly increased the mechanical strength of pHEMA without affecting the hydrophilicity, hemocompatibility, and cytotoxicity. Moreover, the hardness of pHEMA/f-BNNSs composites (38.56 MPa) was remarkably higher than that of pHEMA. There was no cytotoxicity recorded for fabricated bionanocomposites from the MTT assay. All nanocomposites exhibited superior anti-bacterial activities against E.coli and S.aureus compared with pHEMA. However, pHEMA/f-BNNSs composites were more effective against E.coli than S.aureus. While E.coli colonies was reduced 100% at all composites in an hour, S.aureus colonies was completely destroyed with pHEMA/1f-BNNSs and pHEMA/2f-BNNSs after 24 h in-cubation. The study's findings demonstrated that the mechanically improved pHEMA/f-BNNSs films could in-crease the application of pHEMA in biomedical fields.
Açıklama
Anahtar Kelimeler
Boron nitride nanosheets; Biocomposite; Mechanical and biological characterization
Kaynak
Materials Today Communications
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
33
