Importance of Delta Over Baseline Values in Predicting the Severity of Helicobacter pylori Infection in Children

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dc.contributor.authorGuven, Burcu
dc.contributor.authorGulerman, Hacer Fulya
dc.contributor.authorKacmaz, Birgul
dc.date.accessioned2025-01-21T16:41:42Z
dc.date.available2025-01-21T16:41:42Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroduction:Although severe forms of the disease are seen in adults, the Helicobacter pylori (H. pylori) infection is usually acquired during childhood. Therefore, prompt diagnosis of H. pylori infection in childhood is of prime importance. In the present study, we aimed to identify the sensitivity and specificity of 13C urea breath test (UBT) in the diagnosis of H. pylori infection and to assess the severity of the disease with delta over baseline (DOB) values. Materials and Methods: UBT was administered to 200 children who presented with epigastric pain and/or nausea. Esophagogastroduodenoscopy (EGD) was performed in patients. UBT results were compared with histopathological findings. In the Area Under the ROC Curve analysis, a cutoff DOB value was found for the severity of H. pylori infection. Results: 193 children with a mean age of 13.50 +/- 2.98 years were included in the analysis. Of these, 71 (36.8%) patients had a positive UBT and 122 (63.2%) had a negative UBT. EGD was performed in 60 out of 71 patients with positive UBT and in 30 out of 122 patients with negative UBT. The sensitivity and specificity of UBT were 85.1% and 100%. DOB was found to be a significant predictor of moderate/marked H. pylori density at a cutoff value of 6%. Conclusions: The positive correlation detected between the level of DOB values and the density of H. pylori and inflammatory activity can be an advantage for detecting the severity of disease
dc.identifier.doi10.4274/jcp.2021.0006
dc.identifier.endpage45
dc.identifier.issn1304-9054
dc.identifier.issn1308-6308
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85104640654
dc.identifier.scopusqualityQ4
dc.identifier.startpage39
dc.identifier.urihttps://doi.org/10.4274/jcp.2021.0006
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24924
dc.identifier.volume19
dc.identifier.wosWOS:000735332200006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBursa Uludag Univ
dc.relation.ispartofGuncel Pediatri-Journal of Current Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectH. pylori; child; urea breath test
dc.titleImportance of Delta Over Baseline Values in Predicting the Severity of Helicobacter pylori Infection in Children
dc.title.alternativeÇocuklarda helicobacter pylori enfeksiyonunun şiddetini tespit etmede başlangıca göre delta değerlerinin önemi
dc.typeArticle

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