Phosphorus nitrogen compounds: Part 34. Syntheses, structural investigations, cytotoxic and biological activities of spiro-ansa-spiro and spiro-bino-spiro tetrameric phosphazene derivatives

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dc.contributor.authorBerberoglu, Ipek
dc.contributor.authorAsmafiliz, Nuran
dc.contributor.authorKilic, Zeynel
dc.contributor.authorHokelek, Tuncer
dc.contributor.authorKoc, L. Yasemin
dc.contributor.authorAcik, Leyla
dc.contributor.authorDal, Hakan
dc.date.accessioned2020-06-25T18:16:37Z
dc.date.available2020-06-25T18:16:37Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionHokelek, Tuncer/0000-0002-8602-4382; Asmafiliz, Nuran/0000-0002-9335-4101
dc.description.abstractThe reactions of N4P4Cl8 with the symmetric N2N2 (1-3) and N2O2 (4) bulky ligands gave partly substituted 2,4-sas (5 and 6), 2,6-sas (7-10) and sbs (11-14) tetrameric phosphazene derivatives. The 2,4-sas-5, 2,6-sas-8 and sbs-12 reacted with pyrrolidine to give fully-substituted tetra-(15 and 16) and dode-capyrrolidinocyclotetraphosphazenes (17-19). The structures of all the phosphazenes were verified by FTIR, MS, H-1, C-13{H-1} and P-31{H-1} NMR, and HSQC spectral data. The crystal structures of 7, 9 and 10 were examined by single crystal X-ray diffraction techniques. The compounds 1-3, 5, 8, 9, 12, 13, 16 and 18 were screened for antimicrobial activity against G(+) and G(-) bacteria and fungi. The compound 16 is found to possess excellent activity (MIC values of 39 and 78 mu M) against fungal pathogen Candida krusei and Candida albicans. Meanwhile, interactions between pBR322 plasmid DNA and 1-3, 5, 8, 9, 12, 13, 14, 16 and 18 were investigated by agarose gel electrophoresis. The compounds 5, 8, 9, 12, 13, 16 and 18 were appraised for their cytotoxic activity against L929 Fibroblast and MDA-MB-231 breast cancer cell lines. Compounds 13 and 16 are as effective as cis-platin. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipAnkara University, Scientific Research Unit (Turkey) [13B4240001]; Turkish Academy of Sciences - Turkey (Turkiye Bilimler Akademisi)en_US
dc.description.sponsorshipThe authors acknowledge the "Ankara University, Scientific Research Unit (Turkey)" Grant No. 13B4240001. Z.K. thanks the Turkish Academy of Sciences - Turkey (Turkiye Bilimler Akademisi) for partial support of this work.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ica.2016.02.060
dc.identifier.endpage86en_US
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-84960943838
dc.identifier.scopusqualityQ2
dc.identifier.startpage75en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2016.02.060
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6576
dc.identifier.volume446en_US
dc.identifier.wosWOS:000374385600010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclotetraphosphazenesen_US
dc.subjectSynthesesen_US
dc.subjectSpectroscopyen_US
dc.subjectCrystal structureen_US
dc.subjectCytotoxicityen_US
dc.subjectBiological activityen_US
dc.titlePhosphorus nitrogen compounds: Part 34. Syntheses, structural investigations, cytotoxic and biological activities of spiro-ansa-spiro and spiro-bino-spiro tetrameric phosphazene derivativesen_US
dc.typeArticle

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