Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation

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dc.contributor.authorAtan, Ali
dc.contributor.authorBasar, Murad M.
dc.contributor.authorTuncel, Altuğ
dc.contributor.authorFerhat, Mehmet
dc.contributor.authorAgras, Koray
dc.contributor.authorTekdoğan, Ümit
dc.date.accessioned2020-06-25T17:41:07Z
dc.date.available2020-06-25T17:41:07Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.descriptionagras, koray/0000-0003-2484-0648
dc.description.abstractObjectives. To compare the efficacy of sildenafil (Viagra) only, sildenafil plus topical anesthetic cream (EMLA), and topical EMLA-cream-only to that of placebo in treating premature ejaculation. Methods. A total of 84 patients were enrolled in this study. The duration of premature ejaculation in the patients ranged from 9 to 60 months (mean 32.5 +/- 14.6). Patients were randomized into four groups. Group 1 consisted of 20 patients who took placebo for 2 months. Groups 2 and 3 consisted of 20 and 22 patients, respectively, and they received 50 mg sildenafil 45 minutes before coitus for 2 months. In addition, patients in group 3 applied topical EMLA cream to the glans penis 15 minutes before coitus. The 22 patients in group 4 used topical EMLA-cream-only. After at least eight sexual attempts, the patients' clinical responses were assessed using the patient self-description method. Effectiveness was described as improvement plus cure. Results. The effectiveness was 40% in group 1, 55% in group 2, 86.4% in group 3, and 77.3% in group 4. Of the groups, a significant difference was found in the effectiveness of the treatments (Pearson chi-square = 0.00). No significant difference was found between groups 1 and 2 (P = 0.26). Efficacy was more successful in groups 3 and 4 than in the others (P = 0.00). The difference between groups 3 and 4 was not significant (Pearson chi-square = 0.42). Conclusions. Sildenafil-only was not superior to placebo or combination treatment. Topical EMLA-cream-only had equal effectiveness to that of sildenafil plus topical EMLA treatment. The use of topical EMLA-cream-only seems to be an effective treatment of premature ejaculation.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.urology.2005.09.002
dc.identifier.endpage391en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue2en_US
dc.identifier.pmid16461091
dc.identifier.startpage388en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2005.09.002
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3632
dc.identifier.volume67en_US
dc.identifier.wosWOS:000236178500032
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleComparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculationen_US
dc.typeArticle

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