Fasciola hepatica miracidia are dependent on respiration and endogenous glycogen degradation for their energy generation

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dc.contributor.authorBoyunaga H.
dc.contributor.authorSchmitz M.G.J.
dc.contributor.authorBrouwers J.F.H.M.
dc.contributor.authorVan Hellemond J.J.
dc.contributor.authorTielens A.G.M.
dc.date.accessioned2020-06-25T15:13:13Z
dc.date.available2020-06-25T15:13:13Z
dc.date.issued2001
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIt is generally accepted that free-living stages of parasitic helminths are dependent on aerobic degradation of endogenous energy sources for their energy generation. This concept, however, is not the result of extensive experimental evidence, but originated mainly intuitively as oxygen is widely available in their habitat and these stages generally have a small size. Schistosoma mansoni, the sole parasitic helminth whose energy metabolism has been studied throughout its life-cycle indeed has aerobically functioning free-living stages. However, large differences exist in energy metabolism between adult stages of distinct parasitic helminths, and caution should be taken in predicting that all free-living stages of all parasitic helminths have the same, aerobic energy metabolism. Hence, this report studied the energy metabolism of Fasciola hepatica miracidia and demonstrated that F. hepatica miracidia are also dependent on aerobic degradation of their endogenous glycogen stores by glycolysis and on Krebs cycle activity for energy generation. However, in contrast to S. mansoni, F. hepatica miracidia cannot function anaerobically, as inhibition of the respiratory chain blocked motility and carbohydrate degradation, and finally resulted in death of the miracidia. Therefore, this report demonstrated that differences exist between miracidia of distinct species, in pre-adaptation of their energy metabolism to the occasional hypoxic conditions within their next host.en_US
dc.identifier.doi10.1017/S0031182001007211
dc.identifier.endpage173en_US
dc.identifier.issn00311820
dc.identifier.issue2en_US
dc.identifier.pmid11272647
dc.identifier.scopus2-s2.0-0035110108
dc.identifier.scopusqualityQ1
dc.identifier.startpage169en_US
dc.identifier.urihttps://doi.org/10.1017/S0031182001007211
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1671
dc.identifier.volume122en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofParasitology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbohydrate metabolismen_US
dc.subjectFasciola hepaticaen_US
dc.subjectMiracidiumen_US
dc.subjectTrematodeen_US
dc.titleFasciola hepatica miracidia are dependent on respiration and endogenous glycogen degradation for their energy generationen_US
dc.typeArticle

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