Autologous stem cell-derived chondrocyte implantation with bio-targeted microspheres for the treatment of osteochondral defects

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dc.contributor.authorBozkurt, Murat
dc.contributor.authorAsik, Mehmet Dogan
dc.contributor.authorGursoy, Safa
dc.contributor.authorTurk, Mustafa
dc.contributor.authorKarahan, Siyami
dc.contributor.authorGumuskaya, Berrak
dc.contributor.authorDogan, Metin
dc.date.accessioned2020-06-25T18:30:24Z
dc.date.available2020-06-25T18:30:24Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionsimsek, mehmet emin/0000-0002-8081-0550; asik, Mehmet/0000-0001-9154-2697
dc.description.abstractBackground Chondral injury is a common problem around the world. Currently, there are several treatment strategies for these types of injuries. The possible complications and problems associated with conventional techniques lead us to investigate a minimally invasive and biotechnological alternative treatment. Combining tissue-engineering and microencapsulation technologies provide new direction for the development of biotechnological solutions. The aim of this study is to develop a minimal invasive tissue-engineering approach, using bio-targeted microspheres including autologous cells, for the treatment of the cartilage lesions. Method In this study, a total of 28 sheeps of Akkaraman breed were randomly assigned to one of the following groups: control (group 1), microfracture (group 2), scaffold (group 3), and microsphere (group 4). Microspheres and scaffold group animals underwent adipose tissue collection prior to the treatment surgery. Mesenchymal cells collected from adipose tissue were differentiated into chondrocytes and encapsulated with scaffolds and microspheres. Osteochondral damage was conducted in the right knee joint of the sheep to create an animal model and all animals treated according to study groups. Results Both macroscopic and radiologic examination showed that groups 3 and 4 have resulted better compared to the control and microfracture groups. Moreover, histologic assessments indicate hyaline-like cartilage formations in groups 3 and 4. Conclusion In conclusion, we believe that the bio-targeted microspheres can be a more effective, easier, and safer approach for cartilage tissue engineering compared to previous alternatives.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [213M683, 213M716]en_US
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey funded this project under project numbers 213M683 and 213M716.en_US
dc.identifier.citationBozkurt, M., Aşık, M.D., Gürsoy, S. et al. Autologous stem cell-derived chondrocyte implantation with bio-targeted microspheres for the treatment of osteochondral defects. J Orthop Surg Res 14, 394 (2019).en_US
dc.identifier.doi10.1186/s13018-019-1434-0
dc.identifier.issn1749-799X
dc.identifier.issue1en_US
dc.identifier.pmid31779662
dc.identifier.urihttps://doi.org/10.1186/s13018-019-1434-0
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7632
dc.identifier.volume14en_US
dc.identifier.wosWOS:000501331300004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmcen_US
dc.relation.ispartofJournal Of Orthopaedic Surgery And Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCartilageen_US
dc.subjectMicrospheresen_US
dc.subjectBio-targetingen_US
dc.subjectTissue engineeringen_US
dc.titleAutologous stem cell-derived chondrocyte implantation with bio-targeted microspheres for the treatment of osteochondral defectsen_US
dc.typeArticle

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