Evaluation of the Pre-Hemolytic Concentrations of β-, Methyl-β- and Dimethyl-β-Cyclodextrin on Dog and Goat Erythrocytes

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dc.contributor.authorYigit, Ayse Arzu
dc.contributor.authorArikan, Sevket
dc.date.accessioned2020-06-25T17:44:41Z
dc.date.available2020-06-25T17:44:41Z
dc.date.issued2008
dc.description.abstractbeta-Cyclodextrin (beta-CD) is a cage-like molecule consisting of seven glucose units and have appropriate size to form inclusion complexes with many hormones, vitamins and drugs. Due to having very poor aqueous solubility, beta-cyclodextrin is modified chemically for various applications. Experiments were conducted to examine effects of pre-hemolytic concentration of beta-cyclodextrin and its modified derivatives, methyl-beta-cyclodextrin (M beta-CD) and dimethyl-beta-cyclodextrin (DM beta-CD), on the osmotic fragility of dog and goat erythrocytes. Blood samples collected from healthy 10 dogs and 10 goats were analyzed within 5 h of collection. Erythrocyte suspensions were mixed with various concentrations of beta-CD, M beta-CD and DM beta-CD. The mixtures were then incubated for 30 min at 37 degrees C and osmotic fragility of erythrocytes was measured. Incubation of all 3 Cyclo Dextrins (CDs) with erythrocyte suspensions of both species, dog and goat, induced a dose dependent increase in the erythrocyte osmotic fragility (p<0.01). The hemolytic effect was decreased in order DM beta-CD>M beta-CD>beta-CD. Hemolytic doses of these CDs were lower for goat erythrocytes than those of the dog erythrocytes. When beta-CD and its methylated derivatives are even used in pre-hemolytic concentrations, they might also reduce life span of erythrocytes. Due to importance of scientific knowledge on the cellular activity of cyclodextrins and growing number of its potential applications on diagnosis food preparations, our results may help to deal with the hemolytic activity of CDs for in vivo studies.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage580en_US
dc.identifier.issn1680-5593
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-53949092371
dc.identifier.scopusqualityN/A
dc.identifier.startpage575en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4171
dc.identifier.volume7en_US
dc.identifier.wosWOS:000262560800010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMedwell Onlineen_US
dc.relation.ispartofJournal Of Animal And Veterinary Advances
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbeta-Cyclodextrinen_US
dc.subjectdogen_US
dc.subjectgoaten_US
dc.subjectmethyl-beta-Cyclodextrinen_US
dc.subjectosmotic fragilityen_US
dc.titleEvaluation of the Pre-Hemolytic Concentrations of β-, Methyl-β- and Dimethyl-β-Cyclodextrin on Dog and Goat Erythrocytesen_US
dc.typeArticle

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