Multifunctional aptamer-conjugated magnetite graphene oxide/chlorin e6 nanocomposite for combined chemo-phototherapy

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dc.contributor.authorIşıklan, Nuran
dc.contributor.authorHussien, Nizamudin Awel
dc.contributor.authorTürk, Mustafa
dc.date.accessioned2025-01-21T16:42:47Z
dc.date.available2025-01-21T16:42:47Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractHerein, aptamer-functionalized magnetite Fe3O4@graphene oxide/photosensitizer nanocomposite was designed and prepared for chemo-photothermal/photodynamic therapies. Chlorin e6 (Ce6, as a photosensitizer) is used to conjugate with magnetite graphene oxide (Fe3O4@GO). The structure of Fe3O4@GO@Ce6 nanocomposite was characterized by using FTIR, UV, TGA, XRD, VSM and TEM methods. An antineoplastic drug, paclitaxel (Pac), was loaded onto Fe3O4@GO@Ce6 nanocomposite, forming a Fe3O4@GO@Ce6@Pac nanocomplex. The Fe3O4@GO@Ce6 nanocomposite was functionalized with aptamer (Apt) for selective killing of MCF-7 tumor cells. Fe3O4@GO@Ce6@Pac nanocomposite offers a notably enhanced tumor cell photodynamic destruction impact compared to free Ce6. It is displayed that the photothermal impact of magnetite Fe3O4@GO@Ce6 nanocomposite can be used to promote the Ce6 release when irradiated to a near-infrared laser at a low power density, further improving the photodynamic therapy efficiency on tumor cells. It is observed that the Fe3O4@GO@Ce6 nanocomposite possessed good colloidal/photo stability, biocompatibility, and high loading capacity for Pac. Furthermore, compared to the free Ce6, the Fe3O4@GO@Ce6@Apt-Pac nanocomposite display significantly enhanced photodynamic efficacy. Due to its intrinsic optical features, ultrahigh specific surface area, targeting ability, and unique physical interactions with aromatic active agents, Fe3O4@GO@Ce6@Apt-Pac is a promising new nanomaterial for medical and biological applications.
dc.description.sponsorshipScientific Research Projects Coordi-nation Unit of K?r?kkale University [2017/020, 2017/055]
dc.description.sponsorshipAcknowledgment The authors are thankful to the Scientific Research Projects Coordi-nation Unit of K?r?kkale University [Project numbers: 2017/020 and 2017/055, 2017] for their financial support.
dc.identifier.doi10.1016/j.colsurfa.2022.128841
dc.identifier.issn0927-7757
dc.identifier.issn1873-4359
dc.identifier.scopus2-s2.0-85127797125
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.colsurfa.2022.128841
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25132
dc.identifier.volume645
dc.identifier.wosWOS:000797349400005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofColloids and Surfaces A-Physicochemical and Engineering Aspects
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectGraphene oxide; Chlorin e6; Iron oxide; Chemo-phototherapy; Aptamer; Paclitaxel
dc.titleMultifunctional aptamer-conjugated magnetite graphene oxide/chlorin e6 nanocomposite for combined chemo-phototherapy
dc.typeArticle

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