Systemic Immune-Inflammation Index as a Predictor of Asymptomatic Organ Damage in Patients with Newly Diagnosed Treatment-Naive Hypertension

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dc.authoridINANC, IBRAHIM HALIL/0000-0003-4046-6748
dc.contributor.authorInanc, Ibrahim H.
dc.contributor.authorSabanoglu, Cengiz
dc.date.accessioned2025-01-21T16:44:50Z
dc.date.available2025-01-21T16:44:50Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Low-grade inflammation is known to facilitate the development of hypertensive organ damage. The systemic immune-inflammation index (SII) is a new inflammatory index based on circulating immune-inflammatory cells. Objectives: The objectives of this study were to investigate the relationship between the SII and asymptomatic organ damage (AOD) in patients with newly diagnosed treatment-naive hypertension (HTN). Methods: A total of 500 participants (>= 18 years) were enrolled in the study, including 250 patients and 250 healthy volunteers. Microalbuminuria of > 30 mg/day or proteinuria of > 150 mg/day, left ventricular mass index of > 95 g/m(2) in women and > 115 g/m(2) in men, and carotid intima-media thickness of > 0.9 mm or the presence of plaque in the carotid were evaluated as AOD indicators. AOD grade was classified as follows: Grade I - One organ involved, Grade II - Two organs involved, Grade III - Three organs involved, and Grade IV - Four organs involved. Results: SII values were higher among patients with HTN than in the control group. Positive correlations were found between the SII and AOD indicators and C-reactive protein levels. Increasing SII values were a common independent predictor of the presence and severity of AOD. The gradually increasing threshold values of the SII from no AOD to Grade III-IV exhibited high diagnostic performance. Conclusions: High SII values were independent predictors of the presence and severity of AOD in patients with newly diagnosed treatment-naive HTN. Considering the role of inflammation in HTN, the SII, which can be easily evaluated using blood parameters, can be an effective prognostic screening tool. ( REV INVEST CLIN. 2022;74(5):258-67)
dc.identifier.doi10.24875/RIC.22000167
dc.identifier.endpage267
dc.identifier.issn0034-8376
dc.identifier.issn2564-8896
dc.identifier.issue5
dc.identifier.pmid36328003
dc.identifier.startpage258
dc.identifier.urihttps://doi.org/10.24875/RIC.22000167
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25524
dc.identifier.volume74
dc.identifier.wosWOS:000912052400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInst Nacional Nutricion
dc.relation.ispartofRevista De Investigacion Clinica-Clinical and Translational Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectHypertension; End-organ damage; Systemic immune-inflammation index
dc.titleSystemic Immune-Inflammation Index as a Predictor of Asymptomatic Organ Damage in Patients with Newly Diagnosed Treatment-Naive Hypertension
dc.typeArticle

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