Self-powered disposable prothrombin time measurement device with an integrated effervescent pump

Basit Öğe Kaydı
dc.contributor.authorGüler, Mustafa Tahsin
dc.contributor.authorIşıksaçan, Ziya
dc.contributor.authorSerhatlioğlu, Murat
dc.contributor.authorElbüken, Çağlar
dc.date.accessioned2020-06-25T18:29:20Z
dc.date.available2020-06-25T18:29:20Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionSerhatlioglu, Murat/0000-0003-2083-6756; Elbuken, Caglar/0000-0001-8359-6871; GULER, MUSTAFA TAHSIN/0000-0002-0478-3183
dc.description.abstractCoagulation is an essential physiological activity initiated by the interaction of blood components for clot formation. Prothrombin time (PT) measurement is a clinical test for the assessment of the extrinsic/common pathways of coagulation cascade. Periodic measurement of PT is required under numerous conditions including cardiovascular disorders. We present a self-powered microfluidic device for quantitative PT measurement from 50 mu l whole blood. The entire platform is disposable and does not require any external pumping, power, or readout units. It consists of a 3D-printed effervescent pump for CO2 generation from a chemical reaction, a cartridge for two-channel fluid flow (blood and water), and a grid for the quantification of fluid migration distance. Following the introduction of the fluids to the corresponding channel inlets, marking the coagulation start, an acid-base reaction is triggered for gas generation that drives the fluids within the channels. When the blood coagulates, its flow in the channel is halted. At that point, the distance water has travelled is measured using the grid. This distance correlates with PT as demonstrated through clinical tests with patient samples. This single-unit device has a potential for rapid evaluation and periodic monitoring of PT in the clinical settings and at the point-of-care.en_US
dc.description.sponsorshipASELSAN Graduate Scholarship for Turkish Academicians; Scientific and Technologic Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [213S127]en_US
dc.description.sponsorshipThe authors thank Prof. Ozcan Erel for the clinical tests and Dr. Ismail Bilican for the comments on the manuscript. Ziya Isiksacan is supported by ASELSAN Graduate Scholarship for Turkish Academicians. The authors acknowledge support from The Scientific and Technologic Research Council of Turkey (TUBITAK project no. 213S127).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.snb.2018.06.042
dc.identifier.endpage357en_US
dc.identifier.issn0925-4005
dc.identifier.scopus2-s2.0-85048727008
dc.identifier.scopusqualityQ1
dc.identifier.startpage350en_US
dc.identifier.urihttps://doi.org/10.1016/j.snb.2018.06.042
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7251
dc.identifier.volume273en_US
dc.identifier.wosWOS:000441519000045
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Saen_US
dc.relation.ispartofSensors And Actuators B-Chemical
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoagulationen_US
dc.subjectProthrombin timeen_US
dc.subjectMicrofluidicsen_US
dc.subjectChemical pumpen_US
dc.subjectPoint-Of-Careen_US
dc.subject3D printingen_US
dc.titleSelf-powered disposable prothrombin time measurement device with an integrated effervescent pumpen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Self-powered disposable prothrombin time measurement device with an integrated effervescent pump.pdf
Boyut:
1.89 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu