Association between superoxide dismutase 2, glutathione peroxidase 1, xeroderma pigmentosum group d gene variations, and head and neck squamous cell cancer susceptibility

Basit Öğe Kaydı
dc.contributor.authorKose, Gulcin
dc.contributor.authorOz, Merve Demirbugen
dc.contributor.authorComert, Ela
dc.contributor.authorSuzen, Halit Sinan
dc.date.accessioned2025-01-21T16:36:03Z
dc.date.available2025-01-21T16:36:03Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAs oxidative stress is implicated in the pathogenesis of head and neck squamous cell cancer (HNSCC), the functions of antioxidant enzyme systems and DNA repair proteins are critical in the development of cancer. To investigate the role of genetic polymorphisms of the antioxidant superoxide dismutase 2 (SOD2) Val16Ala, glutathione peroxidase 1 (GPX1) Pro198Leu, and the DNA repair Xeroderma Pigmentosum Group D (XPD) Lys751Gln genes under exogenous risk factors, including smoking and alcohol consumption, in HNSCC carcinogenesis, we conducted a case-control study on 139 unrelated cases and 265 non-cancer controls. Polymorphisms were analyzed in additive, dominant and recessive genetic models, individually and in an interaction model. Carriers of the T allele of SOD2 were associated with an increased risk for HNSCC in males and smokers; similarly, the T allele of GPX1 was associated with elevated risk in the overall and smoker subgroup. A 12.47-fold increased risk was observed for the carriers of GPX1 TT, SOD2 CT and XPD CC genotypes for HNSCC. This is the first study presenting the potential roles of SOD2, GPX1 and XPD polymorphisms in interaction and under three genetic models in the development of HNSCC. The results suggest that these polymorphisms slightly modify the risk in HNSCC development individually but are significantly higher when they functioned and were evaluated together.
dc.description.sponsorshipAnkara University Scientific Projects Coordination Unit [08B3336002]
dc.description.sponsorshipThis study was supported by a Grant from the Ankara University Scientific Projects Coordination Unit (08B3336002).
dc.identifier.doi10.2298/ABS220509017K
dc.identifier.endpage189
dc.identifier.issn0354-4664
dc.identifier.issn1821-4339
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85133309863
dc.identifier.scopusqualityQ3
dc.identifier.startpage181
dc.identifier.urihttps://doi.org/10.2298/ABS220509017K
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24243
dc.identifier.volume74
dc.identifier.wosWOS:000871977700008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInst Bioloska Istrazivanja Sinisa Stankovic
dc.relation.ispartofArchives of Biological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjecthead and neck squamous cell cancer; gene polymorphism; GPX1; SOD2; XPD
dc.titleAssociation between superoxide dismutase 2, glutathione peroxidase 1, xeroderma pigmentosum group d gene variations, and head and neck squamous cell cancer susceptibility
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu