Short-term effect of nasal intermittent positive-pressure ventilation in patients with restrictive thoracic disease

dc.contributor.authorErgün, P.
dc.contributor.authorAydin, G.
dc.contributor.authorTurgay, U.Y.
dc.contributor.authorErdoğan, Y.
dc.contributor.authorCağlar, A.
dc.contributor.authorBiber, C.
dc.date.accessioned2020-06-25T17:35:01Z
dc.date.available2020-06-25T17:35:01Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: The use of nasal intermittent positive pressure ventilation (NIPPV) would be expected to ameliorate dyspnea, ventilatory capacity and exercise tolerance durably in individuals with hypercapnic respiratory failure secondary to restrictive thoracic disease. Objectives: The purpose of this study was to determine the short-term effect of NIPPV on respiratory muscle endurance, exercise capacity and respiratory functions in patients with chronic respiratory failure due to restrictive thoracic disease. Methods: Twelve patients with chronic ventilatory failure due to restrictive thoracic disease underwent nasal bilevel positive airway pressure (BiPAP) ventilation for 2 h a day during 15 consecutive days. The effects were assessed by spirometry, arterial blood gas analysis, 6-min walking test, sensation of dyspnea according to the American Thoracic Society dyspnea scoring scales (ATS) and surface electromyogram of the diaphragm (EMGdi) before and after the study (on day 15). Results: Nasal BiPAP reduced the ATS dyspnea score from 2.5 +/- 0.9 to 1.6 +/- 0.4 (p < 0.01). Distances walked in 6 min increased from 320.66 +/- 93.56 to 382.41 +/- 121.20 m (p < 0.05). Comparison of baseline with levels after nasal BiPAP ventilation showed a statistically significant improvement in PaCO2 (p < 0.05). Forced vital capacity increased from 35 to 50% of the predicted value (p < 0.01). There were no statistically significant reductions in the amplitude of EMGdi after the therapy. Conclusion: These results indicate that NIPPV delivered via nasal BiPAP improves respiratory functions, exercise capacity, and reduces dyspnea in the short term in patients with chronic respiratory failure due to restrictive thoracic disease. Whether such short-term improvements can be sustained merits further study. Copyright (C) 2002 S. Karger AG, Basel.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1159/000063268
dc.identifier.endpage308en_US
dc.identifier.issn0025-7931
dc.identifier.issue4en_US
dc.identifier.pmid12169741
dc.identifier.startpage303en_US
dc.identifier.urihttps://doi.org/10.1159/000063268
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2994
dc.identifier.volume69en_US
dc.identifier.wosWOS:000177535100005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKargeren_US
dc.relation.ispartofRespiration
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNIPPVen_US
dc.subjectrestrictive thoracic diseaseen_US
dc.subjectmuscle resten_US
dc.subjectdiaphragm EMGen_US
dc.subjectpulmonary functionen_US
dc.titleShort-term effect of nasal intermittent positive-pressure ventilation in patients with restrictive thoracic diseaseen_US
dc.typeArticle

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