Synthesis, Characterization And Dna Interaction Of Novel Platinum(Ii) Complexes Contaning Substituted Benzimidazole Ligands

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dc.contributor.authorNzeyimana, Abdoul
dc.contributor.authorUtku, Semra
dc.contributor.authorAcik, Leyla
dc.contributor.authorKeskin, Ayten Celebi
dc.date.accessioned2020-06-25T18:23:08Z
dc.date.available2020-06-25T18:23:08Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.description.abstractEight novel Pt(II) complexes corresponding to the following general formula [PtCl2(L-1-L-4)(2)] (C1 -C4) and [PtI2((L1-L4))(2)] (C5-C8) in which 5(6)-chloro/or-methyl-2-H/or-methylbenzimidazole (L-1-L-4) played the key role as carrier ligands were synthesized and characterized by elemental analysis, IR and H-1 NMR. Considering leaving group functions, the anionic ligand iodido and chloro were utilized with the purpose of studying the interaction between the synthesized complexes and pBR322 plasmid DNA by using cisplatin as positive control throughout the Agarose Gel Electrophoresis method. Therefore, looking after plasmid DNA interacting outcomes, synthesized complexes modified the tertiary structure of pBR322 plasmid DNA, and the results showed that the complex C2 ([PtCl2(L-2)(2)]) was highly active compound regarding to all synthesized complexes.en_US
dc.description.sponsorshipMersin University Scientific Research Funds [2015-TP2-1175]en_US
dc.description.sponsorshipWe would like to thank Prof. Dr. Fatma Gumus for her supervision and guidance. This research was financially supported by Mersin University Scientific Research Funds (Grant nos. 2015-TP2-1175).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage236en_US
dc.identifier.issn0035-3930
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85024395325
dc.identifier.scopusqualityQ4
dc.identifier.startpage227en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7016
dc.identifier.volume62en_US
dc.identifier.wosWOS:000403630800004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEditura Acad Romaneen_US
dc.relation.ispartofRevue Roumaine De Chimie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbenzimidazoleen_US
dc.subjectplatinum complexesen_US
dc.subjectsynthesisen_US
dc.subjectgel electrophoresisen_US
dc.subjectcisplatinen_US
dc.titleSynthesis, Characterization And Dna Interaction Of Novel Platinum(Ii) Complexes Contaning Substituted Benzimidazole Ligandsen_US
dc.typeArticle

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