Increased circulating concentrations of PDGF-BB and TGF-?1 in canine generalised demodicosis

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dc.contributor.authorYarim G.F.
dc.contributor.authorYagci B.B.
dc.contributor.authorCiftci G.
dc.date.accessioned2020-06-25T15:17:22Z
dc.date.available2020-06-25T15:17:22Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe purpose of this study was to investigate the changes of circulating concentrations of platelet derived growth factor BB (PDGF-BB) and transforming growth factor beta 1 (TGF-?1) in dogs with generalised demodicosis. Fifteen dogs with generalised demodicosis diagnosed on clinical findings and microscopic examination of the cutaneous scrapings and 10 healthy dogs were included in the study. Circulating concentrations of PDGF-BB and TGF-?1 were measured by commercial specific ELISA assays. Marked and significant increases in plasma PDGF-BB and in serum TGF-?1 concentrations were evidenced in diseased dogs. Circulating PDGF-BB concentrations were closely and positively associated with TGF-?1 concentrations in affected dogs (r = 0.92, p < 0.001). These results indicate that the increased concentrations of circulating PDGF-BB and TGF-?1 play a pivotal role in the pathogenesis of the canine demodicosis.en_US
dc.identifier.endpage17en_US
dc.identifier.issn00351555
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84872116623
dc.identifier.scopusqualityN/A
dc.identifier.startpage13en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2325
dc.identifier.volume164en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofRevue de Medecine Veterinaire
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDogen_US
dc.subjectGeneralised demodicosisen_US
dc.subjectImmune responseen_US
dc.subjectPDGF-BBen_US
dc.subjectSkin repairen_US
dc.subjectTGF-?1en_US
dc.titleIncreased circulating concentrations of PDGF-BB and TGF-?1 in canine generalised demodicosisen_US
dc.typeArticle

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