Capillary electrophoresis in metabolomics

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dc.contributor.authorRamautar, Rawi
dc.contributor.authorDemirci, Ayla
dc.contributor.authorde Jong, Gerhardus J.
dc.date.accessioned2020-06-25T17:43:34Z
dc.date.available2020-06-25T17:43:34Z
dc.date.issued2006
dc.description.abstractThis article describes the potential of capillary electrophoresis (CE) in metabolomics, which concerns the comprehensive analysis of endogenous low-molecular weight compounds in a biological system. Consequently, metabolomic methods are often developed to separate and to detect as many endogenous metabolites as possible in a single analysis. CE is a very powerful technique for this type of profiling. We demonstrate the applicability of CE in different fields of metabolomics research. We show illustrative clinical, bacterial and plant examples and stress the information that CE systems obtain. We distinguish between targeted and non-targeted metabolomic studies in the bacterial and plant sections. We discuss general aspects of sample preparation of CE for biological samples, and pay special attention to the potential of CE-mass spectrometry in metabolomics. We also discuss future developments with regard to sample preparation and the use of hyphenated systems. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.trac.2006.02.004
dc.identifier.endpage466en_US
dc.identifier.issn0165-9936
dc.identifier.issn1879-3142
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-33646123072
dc.identifier.scopusqualityQ1
dc.identifier.startpage455en_US
dc.identifier.urihttps://doi.org10.1016/j.trac.2006.02.004
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3799
dc.identifier.volume25en_US
dc.identifier.wosWOS:000237665400014
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofTrac-Trends In Analytical Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbacterialen_US
dc.subjectcapillary electrophoresisen_US
dc.subjectCEen_US
dc.subjectclinicalen_US
dc.subjectmass spectrometryen_US
dc.subjectmetabolomicsen_US
dc.subjectMSen_US
dc.subjectplanten_US
dc.titleCapillary electrophoresis in metabolomicsen_US
dc.typeArticle

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